Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones
Sriwilaijaroen, N. Liu, M. Go, M.-L. Wilairat, P.
Sriwilaijaroen, N.
Liu, M.
Wilairat, P.
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Abstract
Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.
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Source Title
Southeast Asian Journal of Tropical Medicine and Public Health
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Date
2006-07
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Article