Reciprocal regulation of hippo and wbp2 signalling—implications in cancer therapy
Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin
Lim, Yvonne Xinyi
Lin, Hexian
Seah, Sock Hong
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Alternative Title
Abstract
Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
Cancer, Hippo pathway, Oncogene, Reciprocal regulation, Therapeutics, WW-domain binding protein 2
Source Title
Cells
Publisher
MDPI
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2021-11-11
DOI
10.3390/cells10113130
Type
Review