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Alternative Title
Abstract
Brain development is an energy demanding process that relies heavily upon diet derived nutrients. Gut microbiota enhance the host's ability to extract otherwise inaccessible energy from the diet via fermentation of complex oligosaccharides in the colon. This nutrient yield is estimated to contribute up to 10% of the host's daily caloric requirement in humans and fluctuates in response to environmental variations. Research over the past decade has demonstrated a surprising role for the gut microbiome in normal brain development and function. In this review we postulate that perturbations in the gut microbial-derived nutrient supply, driven by environmental variation, profoundly impacts upon normal brain development and function. © 2014 Landes Bioscience.
Keywords
Glucose, Gut microbiota, Hypothalamic-pituitary-adrenal axis, Metabolism, Microbiota-gut-brain axis, Neurodevelopment, Short chain fatty acids, β-hydroxybutyrate
Source Title
Gut Microbes
Publisher
Series/Report No.
Collections
Rights
Date
2014-03-31
DOI
10.4161/gmic.28681
Type
Review