The effect of raw soybean on oxidative status of digestive organs in mice
Gu, C Qu, H Han, L Song, X Zhao, L Lu, W
Gu, C
Qu, H
Han, L
Song, X
Zhao, L
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Alternative Title
Abstract
The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw soybean diet and Group 3 was fed on raw soybean diet supplemented with 30 mg/kg cysteamine. After two weeks of feeding, duodenum, liver and pancreas samples were collected to measure oxidative and antioxidative parameters. The results show that ingestion of raw soybean markedly increased contents of Superoxide anion and malondialdehyde (MDA) and activity of inducible nitric oxide synthase (iNOS), decreased activity of Superoxide dismutase (SOD), T-AOC and content of reduced glutathione (GSH) in digestive organs of mice (P < 0.05). In the group fed with raw soybean diet supplemented with cysteamine, oxidative stress was mitigated. However, oxidative parameter levels were still higher than those of control diet-fed group. The present study indicates that ingestion of raw soybean could result in an imbalance between oxidant and antioxidant, and thus induce oxidative stress in digestive organs of mice. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Keywords
free radical, glutathione, inducible nitric oxide synthase, malonaldehyde, mercaptamine, reactive oxygen metabolite, superoxide, superoxide dismutase, glutathione, inducible nitric oxide synthase, malonaldehyde, soybean protein, superoxide, superoxide dismutase, animal experiment, animal tissue, article, controlled study, diet supplementation, dietary intake, digestive system, duodenum mucosa, enzyme activity, lipid peroxidation, liver parenchyma, male, mouse, nonhuman, nutritional assessment, oxidative stress, pancreas function, raw food, soybean, animal, C57BL mouse, chemistry, drug effects, duodenum, eating, liver, metabolism, pancreas, soybean, Animals, Duodenum, Eating, Glutathione, Liver, Male, Malondialdehyde, Mice, Mice, Inbred C57BL, Nitric Oxide Synthase Type II, Oxidative Stress, Pancreas, Soybean Proteins, Soybeans, Superoxide Dismutase, Superoxides
Source Title
International Journal of Molecular Sciences
Publisher
Series/Report No.
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Rights
Attribution 4.0 International
Date
2011
DOI
10.3390/ijms12128836
Type
Article