Cost-effectiveness of osteo-odonto keratoprosthesis in Singapore
Dong, D. Tan, A. Mehta, J.S. Tan, D. Finkelstein, E.A.
Dong, D.
Tan, A.
Tan, D.
Finkelstein, E.A.
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Abstract
Purpose To determine the long-term cost-effectiveness of osteo-odonto keratoprosthesis (OOKP) relative to no treatment among patients with end-stage corneal and ocular surface diseases in Singapore. Design Cost-effectiveness analysis based on data from a retrospective cohort study. Methods From a health system perspective, we calculated the incremental cost-effectiveness ratio of OOKP treatment relative to no treatment over a 30-year horizon, based on data from a cohort of 23 patients who underwent OOKP surgery between 2004 and 2009 at Singapore National Eye Centre. Preoperative and postoperative vision-related quality-of-life values were estimated from patients' visual outcomes and were used to calculate the gain in quality-adjusted life years (QALYs) resulting from OOKP treatment. Unsubsidized costs for surgery, consultations, examinations, medications, follow-up visits, and treatments for complications were retrieved from patients' bills to estimate the total costs associated with OOKP treatment. Sensitivity analyses were conducted to test the robustness of the model. Results Over a 30-year period, OOKP treatment, compared with no treatment, improved QALYs by 3.991 among patients with end-stage corneal and ocular surface diseases at an additional cost of S$67 840 (US$55 150), resulting in an incremental cost-effectiveness ratio of S$17 000/QALY (US$13 820/QALY). Conclusions Based on commonly cited cost-effectiveness benchmarks, the OOKP is a cost-effective treatment for patients with end-stage corneal and ocular surface diseases. © 2014 by Elsevier Inc. All rights reserved.
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Source Title
American Journal of Ophthalmology
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Date
2014-01
DOI
10.1016/j.ajo.2013.08.004
Type
Article