Rab35 - A vesicular traffic-regulating small GTPase with actin modulating roles
Chua, C.E.L. Lim, Y.S. Tang, B.L.
Chua, C.E.L.
Lim, Y.S.
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Alternative Title
Abstract
The Rab family of GTPases are regulators of eukaryotic vesicular membrane traffic, while modulation of actin dynamics is a function conventionally associated with the Rho family of GTPases. Rab35 is a Rab protein with both plasma membrane and endosomal localization, and has been implicated in diverse processes that include T-cell receptor recycling, oocyte yolk protein recycling and cytokinesis. Rab35 regulates neurite outgrowth in neuronal-like cells, and can induce protrusions even in typically non-adherent Jurkat T-cells. Recent evidence indicates that Rab35's activity, particularly the ability to mediate protrusive outgrowths, is due to its direct influence on actin dynamics. This can occur via activation of the Rho family of GTPases, or through the engagement of its effector fascin, an actin bundling protein. © 2009 Federation of European Biochemical Societies.
Keywords
Actin, Cdc42, Cytokinesis, Fascin, Rab35
Source Title
FEBS Letters
Publisher
Series/Report No.
Collections
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Date
2010
DOI
10.1016/j.febslet.2009.11.051
Type
Review