Polymer-coated hollow fiber microextraction combined with on-column stacking in capillary electrophoresis
Basheer, C. Wang, H. Jayaraman, A. Valiyaveettil, S. Lee, H.K.
Wang, H.
Jayaraman, A.
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Abstract
In this work, a novel microextraction method termed polymer-coated hollow fiber microextraction (PC-HFME) was developed in combination with capillary electrophoresis (CE). Polar dihydroxylated polymethalmethacrylate polymer was coated onto a porous propylene hollow fiber membrane and used as an adsorbent and that was placed in a stirred aqueous sample solution. Tumbling of the extraction device within the sample solution facilitated extraction. The amino alcohols (2-amino-1-phenylethanol, norephedrine, alprenolol and atenolol which are β-blocker drugs), were used as model compounds to investigate the extraction performance. No organic solvent was used in this procedure. The extract was then further concentrated through on-column stacking (normal stacking mode) during CE analysis. The detection limits ranged from 0.9 to 7 ng ml-1. Relative standard deviations (n = 6) ranged from 4 to 6%. The extraction of the amino alcohols in spiked wastewater effluent (representing a complex matrix) was evaluated using the developed procedure. © 2006 Elsevier B.V. All rights reserved.
Keywords
Amino alcohols, Capillary electrophoresis, Functional polymers and hollow fiber, Microextraction, Stacking
Source Title
Journal of Chromatography A
Publisher
Series/Report No.
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Date
2006-09-22
DOI
10.1016/j.chroma.2006.06.040
Type
Article