Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: Single nucleotide and haplotype analyses
Pan, X.-F. Yang, S.-J. Loh, M. Xie, Y. Wen, Y.-Y. Tian, Z. Huang, H. Lan, H. Chen, F. Soong, R.
Pan, X.-F.
Yang, S.-J.
Loh, M.
Xie, Y.
Wen, Y.-Y.
Tian, Z.
Huang, H.
Lan, H.
Chen, F.
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Alternative Title
Abstract
Objectives: Interleukin (IL)-10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. Methods: We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. Results: Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P≤0.01) and alcohol drinking (54.6% versus 43.2%, PG were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. Conclusions: In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.
Keywords
Case, Gastric cancer, Interleukin-10 gene, Ontrol study, Polymorphism, Risk
Source Title
Asian Pacific Journal of Cancer Prevention
Publisher
Series/Report No.
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Date
2013
DOI
10.7314/APJCP.2013.14.4.2577
Type
Article