Lee Jon Deoon,Edmund
Email Address
phcelee@nus.edu.sg
Organizational Units
YONG LOO LIN SCH OF MEDICINE
faculty
PHARMACOLOGY
dept
71 results
Publication Search Results
Now showing 1 - 10 of 71
Publication Pharmacogenomic diversity in Singaporean populations and Europeans(NATURE PUBLISHING GROUP, 2014-12-01) Brunham, LR; Chan, SL; Li, R; Aminkeng, F; Liu, X; Saw, WY; Ong, RTH; Pillai, EN; Carleton, BC; Toh, D; Tan, SH; Koo, SH; Lee, EJD; Chia, KS; Ross, CJD; Hayden, MR; Sung, C; Teo, YY; Dr XXX Folefac Aminkeng; PHARMACOLOGY; MEDICINE; DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL); SAW SWEE HOCK SCHOOL OF PUBLIC HEALTHDifferences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian populations to determine if the allelic differentiation corresponded to an excess of the associated ADR. We identified an excess of ADRs related to clopidogrel in Singaporean Chinese, consistent with a higher frequency of a known risk variant in CYP2C19 in that population. We also observed an excess of ADRs related to platinum compounds in Singaporean CHS, despite a very low frequency of known ADR risk variants, suggesting the presence of additional genetic and non-genetic risk factors. Our results point to substantial diversity at specific pharmacogenomic loci that may contribute to inter-population variability in drug response phenotypes.Publication Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victims(2009) Banerjee, B.; Peiris, D.N.; Hande, M.P.; Koo, S.H.; Lee, E.J.D.; Chui, P.; PHARMACOLOGY; PHYSIOLOGYPublication The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects(2008) Adkison, K.K.; Vaidya, S.S.; Mehta, A.A.; Lee, D.Y.; Polli, J.W.; Lou, Y.; Koo, S.H.; Li, L.; Lee, E.J.D.; Gross, A.S.; PHARMACOLOGYPublication Stereochemistry in therapeutics. Knowing what the left hand is doing(1991) Lee, E.J.D.; PHARMACOLOGYPublication Genomic copy number variations in three southeast Asian populations(2010) Ku, C.-S.; Sim, X.; Ong, R.T.H.; Teo, Y.-Y.; Chia, K.-S.; Salim, A.; Pawitan, Y.; Seielstad, M.; Lee, E.J.D.; PHARMACOLOGY; CENTRE FOR MOLECULAR EPIDEMIOLOGY; STATISTICS & APPLIED PROBABILITY; EPIDEMIOLOGY & PUBLIC HEALTH; LIFE SCIENCES INSTITUTEPublication Virtual integrated patient: An ai supplementary tool for second-year medical students(Yong Loo Lin School of Medicine, 2021-01-01) Kong, JSM; Teo, BS; Lee, YJ; Pabba, AB; Lee, EJD; Sng, JCG; Dr Chia Ghee Judy Sng; PHARMACOLOGYIntroduction: With the COVID-19 pandemic, Singapore underwent a national lockdown in which most organisations, including schools were closed. Halting face-to-face tutorials resulting in decreased clinical contact for medical students. Prior to the pandemic, we had developed the Virtual Integrated Patient (VIP). Equipped with conversational technology, it provides students online practice in various clinical skills such as history-taking, physical examination and investigations. The aim of this paper is to describe the supplementary use of VIP in the second-year class, in which a pilot study was conducted. Methods: The VIP platform was introduced to the cohort and used to supplement the teaching of history-taking in the “Communication with Patients” (CWP) module for second-year students. Traditionally, CWP tutorials involve face-to-face history-taking from standardised patients (SPs). Students, who consented to participating in the trial, had an additional 3 weeks’ access to VIP to practice their history-taking skills. They completed a survey on their user experience and satisfaction at the end of the 3 weeks. Results: Out of the 106 participants, 87% strongly agreed or agreed that using VIP helped in remembering the content while 69% of them felt that VIP increased their confidence and competence in history-taking. Conclusion: VIP was well-received by students and showed promise as a tool to supplement history-taking tutorials, prior to students’ encounter with SPs and real patients. Hence, this trend showed its potential as an alternative when clinical rotations were delayed or cancelled. Further research can be done to evaluate its effectiveness in this context.Publication Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations(2009) Teo, Y.-Y.; Sim, X.; Ong, R.T.H.; Ku, C.-S.; Chia, K.-S.; Small, K.S.; Tan, A.K.S.; Chen, J.; Tantoso, E.; Seielstad, M.; Lee, E.J.D.; PHARMACOLOGY; CENTRE FOR MOLECULAR EPIDEMIOLOGY; STATISTICS & APPLIED PROBABILITY; EPIDEMIOLOGY & PUBLIC HEALTHPublication Thiopurine S-methyltransferase activity in a Chinese population(1993-07) Lee, E.J.D.; Kalow, W.; PHARMACOLOGYThiopurine S-methyltransferase is a cytosolic enzyme that catalyzes the S-methylation of thiopurine drugs. Although a genetic polymorphism has been recognized for this enzyme in populations of Caucasian descent, there has been scanty information about this polymorphism among Asians. In this study, we measured the erythrocyte thiopurine methyltransferase activity in 119 healthy Chinese subjects by a radiochemical assay. Methyltransferase activity was lower than what might have been expected for a white population. A bimodal frequency distribution was obtained that allowed the identification of four individuals with relatively low methyltransferase activity who may be heterozygotes for thiopurine S-methyltransferase deficiency; if so, the frequency of the mutant allele would be lower in this Chinese population than that observed in a white population (χ2, p < 0.02). No gender-based differences were observed. Copyright © 1993 by Mosby-Year Book, Inc.Publication Effect of dietary purines on the pharmacokinetics of orally administered ribavirin(2009) Li, L.; Koo, S.H.; Limenta, L.M.G.; Han, L.; Lee, E.J.D.; Hashim, K.B.; Quek, H.H.; PHARMACOLOGYPublication Genetics of ion channels in sudden unexplained death syndrome: Moving beyond idiopathic reactions to personalized risk assessment(2008) Koo, S.H.; Lee, E.J.D.; Chui, P.; PHARMACOLOGY