Seow See Voon

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paessv@nus.edu.sg


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2003 - 200932010 - 20111
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Now showing 1 - 4 of 4
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    Publication
    Molecule
    (2011-08-16) CHUA, KAW YAN; SEOW, SEE VOON; KOLATKAR, PRASANNA RATNAKAR; BIOLOGICAL SCIENCES; PAEDIATRICS; NATIONAL UNIVERSITY OF SINGAPORE
    We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. Uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.
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    Publication
    A 1.7 Å structure of Fve, a member of the new fungal immunomodulatory protein family
    (2003) Paaventhan, P.; Joseph, J.S.; Kolatkar, P.R.; Seow, S.V.; Chua, K.Y.; Vaday, S.; Robinson, H.; PAEDIATRICS
    Fve, a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity, stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and edema, enhances transcription of IL-2, IFN-γ and TNF-α, and hemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve is a non-covalently linked homodimer containing no Cys, His or Met residues. It shares sequence similarity only to the other fungal immunomodulatory proteins (FIPs) LZ-8, Gts, Vvo and Vvl, all of unknown structure. The 1. 7Å structure of Fve solved by single anomalous diffraction of NaBr-soaked crystals is novel: each monomer consists of an N-terminal α-helix followed by a fibronectin III (FNIII) fold. The FNIII fold is the first instance of "pseudo-h-type" topology, a transition between the seven β-stranded s-type and the eight β-stranded h-type topologies. The structure suggests that dimerization, critical for the activity of FIPs, occurs by 3-D domain swapping of the N-terminal helices and is stabilized predominantly by hydrophobic interactions. The structure of Fve is the first in this lectin family to be reported, and the first of an FNIII domain-containing protein of fungal origin. © 2003 Elsevier Ltd. All rights reserved.
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    Publication
    Coadministration of the fungal immunomodulatory protein FIP-Fve and a tumour-associated antigen enhanced antitumour immunity
    (2009) Ding, Y.; Seow, S.V.; Huang, C.H.; Liew, L.M.; Kuo, I.C.; Chua, K.Y.; Lim, Y.C.; PAEDIATRICS; PATHOLOGY
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    Publication
    Crystallization and preliminary X-ray crystallographic studies on the fungal immunomodulatory protein Fve from the golden needle mushroom (Flammulina velutipes)
    (2003) Seow, S.V.; Kuo, I.-C.; Chua, K.Y.; Paaventhan, P.; Kolatkar, P.R.; GENOME INSTITUTE OF SINGAPORE; PAEDIATRICS