Lim Su Lin

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csilsl@nus.edu.sg


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Now showing 1 - 4 of 4
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    The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore
    (IOS PRESS, 2019-01-01) FENG, LEI; CHEAH, IRWIN KEE-MUN; NG, MAISIE MEI-XI; LI, JIALIANG; CHAN, SUE MEI; LIM, SU LIN; MAHENDRAN, RATHI; KUA, EE-HEOK; HALLIWELL, BARRY; Dr Irwin Cheah Kee-Mun; DEAN'S OFFICE (MEDICINE); STATISTICS & APPLIED PROBABILITY; PSYCHOLOGICAL MEDICINE; BIOCHEMISTRY
    © 2019 - IOS Press and the authors. All rights reserved. We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0.23-0.78, p = 0.006) and this association was independent of age, gender, education, cigarette smoking, alcohol consumption, hypertension, diabetes, heart disease, stroke, physical activities, and social activities. Our cross-sectional data support the potential role of mushrooms and their bioactive compounds in delaying neurodegeneration.
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    Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells
    (Impact Journals LLC, 2014) Chien W.; Ding L.-W.; Sun Q.-Y.; Torres-Fernandez L.A.; Tan S.Z.; Xiao J.; Lim S.L.; Garg M.; Lee K.L.; Kitajima S.; Takao S.; Leong W.Z.; Sun H.; Tokatly I.; Poellinger L.; Gery S.; Koeffler P.H.; MEDICINE; CANCER SCIENCE INSTITUTE OF SINGAPORE; DUKE-NUS MEDICAL SCHOOL; PATHOLOGY
    Endoplasmic reticulum stress from unfolded proteins is associated with the proliferation of pancreatic tumor cells, making the many regulatory molecules of this pathway appealing targets for therapy. The objective of our study was to assess potential therapeutic efficacy of inhibitors of unfolded protein response (UPR) in pancreatic cancers focusing on IRE1? inhibitors. IRE1?-mediated XBP-1 mRNA splicing encodes a transcription factor that enhances transcription of chaperone proteins in order to reverse UPR. Proliferation assays using a panel of 14 pancreatic cancer cell lines showed a dose- and time-dependent growth inhibition by IRE1?-specific inhibitors (STF-083010, 2-Hydroxy-1-naphthaldehyde, 3-Ethoxy-5,6-dibromosalicylaldehyde, toyocamycin). Growth inhibition was also noted using a clonogenic growth assay in soft agar, as well as a xenograft in vivo model of pancreatic cancer. Cell cycle analysis showed that these IRE1? inhibitors caused growth arrest at either the G1 or G2/M phases (SU8686, MiaPaCa2) and induced apoptosis (Panc0327, Panc0403). Western blot analysis showed cleavage of caspase 3 and PARP, and prominent induction of the apoptotic molecule BIM. In addition, synergistic effects were found between either STF-083010, 2-Hydroxy-1-naphthaldehyde, 3-Ethoxy-5,6-dibromosalicylaldehyde, or toyocamycin and either gemcitabine or bortezomib. Our data suggest that use of an IRE1? inhibitor is a novel therapeutic approach for treatment of pancreatic cancers.
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    ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion
    (Ferrata Storti Foundation, 2018) Madan, V.; Han, L.; Hattori, N.; Woon Teoh, W.; Mayakonda, A.; Sun, Q.-Y.; Ding, L.-W.; Mohd Nordin, H.B.; Lim, S.L.; Shyamsunder, P.; Dakle, P.; Sundaresan, J.; Doan, N.B.; Sanada, M.; Sato-Otsubo, A.; Meggendorfer, M.; Yang, H.; Said, J.W.; Ogawa, S.; Haferlach, T.; Liang, D.-C.; Shih, L.-Y.; Nakamaki, T.; Wang, Q.T.; Koeffler, H.P.; MEDICINE; CANCER SCIENCE INSTITUTE OF SINGAPORE; DUKE-NUS MEDICAL SCHOOL
    Chromosomal translocation t(8;21)(q22;q22) which leads to the generation of oncogenic RUNX1-RUNX1T1 (AML1-ETO) fusion is observed in approximately 10% of acute myelogenous leukemia (AML). To identify somatic mutations that co-operate with t(8;21)-driven leukemia, we performed whole and targeted exome sequencing of an Asian cohort at diagnosis and relapse. We identified high frequency of truncating alterations in ASXL2 along with recurrent mutations of KIT, TET2, MGA, FLT3, and DHX15 in this subtype of AML. To investigate in depth the role of ASXL2 in normal hematopoiesis, we utilized a mouse model of ASXL2 deficiency. Loss of ASXL2 caused progressive hematopoietic defects characterized by myeloid hyperplasia, splenomegaly, extramedullary hematopoiesis, and poor reconstitution ability in transplantation models. Parallel analyses of young and >1-year old Asxl2-deficient mice revealed age-dependent perturbations affecting, not only myeloid and erythroid differentiation, but also maturation of lymphoid cells. Overall, these findings establish a critical role for ASXL2 in maintaining steady state hematopoiesis, and provide insights into how its loss primes the expansion of myeloid cells. © 2018 Ferrata Storti Foundation.
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    SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway
    (John Wiley and Sons Ltd, 2015) Sun Qiao Yang; Ding Ling Wen; Xiao Jin Fen; Chien Wen Wen; Lim Su Lin; Hattori Norimichi; Goodglick Lee; Chia David; Mah Vei; Alavi Mohammad; Kim S.R.,; Doan N.B.; Said J.W; Loh Xin Yi; Xu Liang; Liu Li Zhen; Yang Henry; Takahide Hayano; Shi Shuo; Xie Dong; Lin De Chen; Koeffler Philip H.; CANCER SCIENCE INSTITUTE OF SINGAPORE