Luke P. Lee
Email Address
bielpsl@nus.edu.sg
4 results
Publication Search Results
Now showing 1 - 4 of 4
Publication A Handheld Point-of-Care Genomic Diagnostic System(Public Library of Science (PLoS), 2013) Myers F.B.; Henrikson R.H.; Bone J.; Lee L.P.; BIOMEDICAL ENGINEERINGPublication Point-of-care diagnostic tests for tuberculosis disease(American Association for the Advancement of Science (AAAS), 2022-04-06) Hong, Jia Mei; Lee, Hyeyoung; Menon, Nishanth V; Lim, Chwee Teck; Lee, Luke P; Ong, Catherine WM; Dr Wei Min Catherine Ong; BIOMEDICAL ENGINEERING; MEDICINE; BIOMED INST FOR GLOBAL HEALTH RES & TECHRapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.Publication Quantum biological tunnel junction for electron transfer imaging in live cells(Nature Publishing Group, 2019) Xin, H.; Sim, W.J.; Namgung, B.; Choi, Y.; Li, B.; Lee, L.P.; BIOMEDICAL ENGINEERING; BIOMED INST FOR GLOBAL HEALTH RES & TECHQuantum biological electron transfer (ET) essentially involves in virtually all important biological processes such as photosynthesis, cellular respiration, DNA repair, cellular homeostasis, and cell death. However, there is no real-time imaging method to capture biological electron tunnelling in live cells to date. Here, we report a quantum biological electron tunnelling (QBET) junction and its application in real-time optical detection of QBET and the dynamics of ET in mitochondrial cytochrome c during cell life and death process. QBET junctions permit to see the behaviours of electron tunnelling through barrier molecules with different barrier widths. Using QBET spectroscopy, we optically capture real-time ET in cytochrome c redox dynamics during cellular apoptosis and necrosis in living cells. The non-invasive real-time QBET spectroscopic imaging of ET in live cell open a new era in life sciences and medicine by providing a way to capture spatiotemporal ET dynamics and to reveal the quantum biological mechanisms. © 2019, The Author(s).Publication A real-time PCR antibiogram for drug-resistant sepsis(Public Library of Science (PLoS), 2011) Waldeisen J.R.; Wang T.; Mitra D.; Lee L.P.; BIOMEDICAL ENGINEERING