CHAI SIAW CHING
Email Address
bchcsc@nus.edu.sg
Organizational Units
YONG LOO LIN SCH OF MEDICINE
faculty
BIOCHEMISTRY
dept
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Publication CHOLESTEROL BIOSYNTHESIS PATHWAY MODULATORS AND USES THEREOF(2006-03-22) JEYASEELAN, KANDIAH; ARMUGAM, ARUNMOZHIARASI; CHAI, SIAW CHING; RAMKISHEN, PRABHAKARAN N; GOPALAKRISHNAKONE, PONNAMPALAM; TAN, KWONG HUAT BENNY; PHARMACOLOGY; ANATOMY; BIOCHEMISTRYAn isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof.Publication Cholesterol biosynthesis pathway modulators and uses thereof(2006-10-05) JEYASEELAN, KANDIAH; ARMUGAM, ARUNMOZHIARASI; CHAI, SIAW CHING; RAMKISHEN, PRABHAKARAN NAIR; GOPALAKRISHNAKONE, PONNAMPALAM; TAN, KWON HUAT BENNY; PHARMACOLOGY; ANATOMY; BIOCHEMISTRYAn isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof.Publication CHOLESTEROL BIOSYNTHESIS PATHWAY MODULATORS AND USES THEREOF(2004-12-16) JEYASEELAN, KANDIAH; ARMUGAM, ARUNMOZHIARASI; CHAI, SIAW CHING; RAMKISHEN, PRABHAKARAN N; GOPALAKRISHNAKONE, PONNAMPALAM; TAN, KWONG HUAT BENNY; PHARMACOLOGY; ANATOMY; BIOCHEMISTRYAn isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof.Publication CHOLESTEROL BIOSYNTHESIS PATHWAY MODULATORS AND USES THEREOF(2010-08-04) JEYASEELAN, KANDIAH; ARMUGAM, ARUNMOZHIARASI; CHAI, SIAW CHING; RAMKISHEN, PRABHAKARAN, N.; GOPALAKRISHNAKONE, PONNAMPALAM; TAN, KWONG HUAT BENNY; PHARMACOLOGY; ANATOMY; BIOCHEMISTRY-