Marian Priyanthi Kumarasinghe
Email Address
patmpk@nus.edu.sg
Organizational Units
YONG LOO LIN SCH OF MEDICINE
faculty
PATHOLOGY
dept
6 results
Publication Search Results
Now showing 1 - 6 of 6
Publication HBME-1 and CK19 are highly discriminatory in the cytological diagnosis of papillary thyroid carcinoma(2008) Nga, M.-E.; Lim, G.S.; Son, C.H.; Kumarasinghe, M.P.; PATHOLOGYPublication Spontaneous inferior epigastric artery pseudoaneurysm(2010-06) Venkatesh, S.K.; Reynolds, V.B.; Sidhu, H.R.; Maran, P.K.; DIAGNOSTIC RADIOLOGY; PATHOLOGYA case of spontaneous pseudoaneurysm of the inferior epigastric artery-diagnosed on Doppler sonography-is presented. A 19-year-old boy presented with a lump in the anterior abdominal wall. Clinically a smooth, nontender, and noncompressible mass was present above umbilicus to the right of midline. A bruit was heard over the swelling. Doppler sonography demonstrated an oval hypoechoic structure in the right rectus sheath with turbulent flow. The pseudoaneurysm could be traced to the inferior epigastric artery. Surgical excision of pseudoaneurysm was performed. Histopathology showed myxoid changes in the wall of the pseudoaneurysm with no inflammatory changes. © 2010 Wiley Periodicals, Inc.Publication Endoscopic biopsy features and diagnostic challenges of adult Crohn's disease at initial presentation(2010-02) Kumarasinghe, M.P.; Quek, T.P.; Chau, C.Y.P.; Mustapha, N.R.N.; Luman, W.; Ooi, C.J.; DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE; PATHOLOGYAims: Endoscopic biopsy diagnosis of Crohn's disease (CD) is problematic due to lack of specific microscopic features and patchy involvement. There is no documentation of the pattern and severity of microscopic features of CD at initial presentation in adults or children. We aimed to assess the initial mucosal biopsy features of CD in adults and to identify any specific features to confirm the diagnosis. Methods: Thirty sets of initial, adult endoscopic biopsies suspected to be CD with subsequent resections, repeat biopsies with long-term follow-up, and/or other confirmatory laboratory results were analysed by three gastrointestinal pathologists, blinded for the final diagnosis for mucosal architectural changes, epithelial abnormalities, chronic and active inflammation and changes of muscularis mucosae and submucosa. There were 25 cases of CD and five cases of non-CD for comparison (3 tuberculosis and 2 right-sided diverticular disease and associated colitis). Cases confirmed as ulcerative colitis were excluded, as diagnostic challenges are already well established. Results: The majority of initial biopsies (96%) of CD were abnormal with active chronic ileocolitis with a very high proportion (80%) showing the classic combination of abnormal mucosal architecture, epithelial abnormalities and active chronic inflammation. The most sensitive feature was lamina proprial chronic inflammation (sensitivity 92.7%). Sensitivity for other features was as follows: active inflammation 87.8%, basal plasmacytosis 82.1%, architectural changes 80.5% and epithelial abnormalities 70.7%. Abnormalities were found in 94% of ileal and 76% of colonic biopsies. No feature was specific as all tuberculosis and diverticular disease cases showed the classic combination. Granulomata were seen in 10 of 41 CD, in all five tuberculosis and in no diverticular disease biopsies. Small, tight, well defined granulomata characterised CD over large coalesced ganulomata of tuberculosis. Paneth cell and pseudopyloric metaplasia was seen only in CD (2/25). Conclusions: Initial endoscopic biopsies of adult CD are significantly abnormal and a majority shows active chronic ileocolitis. The features are sufficiently important to suspect CD at initial presentation in the appropriate clinical setting. Tuberculosis and diverticular disease associated colitis are two important mimics to consider in addition to ulcerative colitis. © 2010 Royal College of Pathologists of Australasia.Publication Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors(2010) Yan, B.; Wang, S.; Lee, C.K.; Salto-Tellez, M.; Kumarasinghe, M.P.; Yap, C.T.; Koh, S.; Omar, M.F.; PHYSIOLOGY; NATIONAL UNIVERSITY MEDICAL INSTITUTES; PATHOLOGYGastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors. © 2008 Elsevier GmbH. All rights reserved.Publication RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis(2009) Subramaniam, M.M.; Chan, J.Y.; Soong, R.; Ito, K.; Ito, Y.; Salto-Tellez, M.; Chen, C.L.; Kumarasinghe, M.P.; Yeoh, K.G.; Wong, R.; Guenther, T.; Will, O.; MEDICINE; NATIONAL UNIVERSITY MEDICAL INSTITUTES; CANCER SCIENCE INSTITUTE OF SINGAPORE; PATHOLOGYPublication A 57-year-old Malay man with per rectal bleeding(2005) Yu, H.K.; Low, A.; Kumarasinghe, P.; Hwang, J.; MEDICINE; PATHOLOGY