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Issue DateTitleAuthor(s)
2000Molecular cloning, heterologous expression, and functional characterisation of a malate synthase gene from Streptomyces coelicolor A3(2)Loke, P. ; Sim, T.-S. 
2000Molecular studies on isopenicillin N synthasesSim, T.S. ; Loke, P. 
2000Molecular studies on isopenicillin N synthasesSim, T.S. ; Loke, P. 
2001Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
2001Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
2000Mutational analysis of tyrosine-191 in the catalysis of Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
2000Mutational analysis of tyrosine-191 in the catalysis of Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-W. 
15-Aug-1998Mutational evidence for the role of serine-283 in Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
1998Mutational evidence for the role of serine-283 in Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
2000PCR cloning, heterologous expression, and characterization of isopenicillin N synthase from Streptomyces lipmanii NRRL 3584Loke, P. ; Ng, C.P.; Sim, T.-S. 
2000PCR cloning, heterologous expression, and characterization of isopenicillin N synthase from Streptomyces lipmanii NRRL 3584Loke, P. ; Ng, C.P.; Sim, T.-S. 
2001PCR-mediated screening and cloning of a malate synthase gene from Streptomyces griseus NCIMB 9001Loke, P. ; Wee, J.; Keng, Ing Seah; Sim, T.-S. 
2001PCR-mediated screening and cloning of a malate synthase gene from Streptomyces griseus NCIMB 9001Loke, P. ; Wee, J.; Keng Ing Seah; Sim, T.-S. 
2002Purification and characterization of recombinant malate synthase enzymes from streptomyces coelicolor a3(2) and s. clavuligerus Nrrl3585Loke, P. ; Goh, L.-L.; SOH BOON SENG ; Yeow, P.; Sim, T.-S. 
2001Replacement of arginine-171 and aspartate-453 in Streptomyces coelicolor malate synthase A by site-directed mutagenesis inactivates the enzymeGoh, L.-L.; Loke, P. ; Sim, T.-S. 
2001Replacement of tyrosine-197 and the corresponding tyrosine-195 to isoleucine in Cephalosporium acremonium and Streptomyces clavuligerus isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
1999Site-directed mutagenesis of arginine-89 supports the role of its guanidino side-chain in substrate binding by Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
15-Oct-1999Site-directed mutagenesis of arginine-89 supports the role of its guanidino side-chain in substrate binding by Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, T.-S. 
2001Site-Directed Mutagenesis of Proline-285 to Leucine in Cephalosporium acremonium Isopenicillin N - Synthase Affects Catalysis and Increases Soluble Expression at Higher TemperaturesLoke, P. ; Sim, T.-S. 
2003Soluble expression of a functionally active Plasmodium falciparum falcipain-2 fused to maltose-binding protein in Escherichia coliGoh, L.L.; Singh, M. ; Sim, T.S. ; Loke, P.