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Showing results 5 to 24 of 24 < previous 
Issue DateTitleAuthor(s)
Dec-2007In vitro metabolism of leflunomide by mouse and human liver microsomes.Chan, E.C. ; New, L.S. 
Jul-2012Interaction of lapatinib with cytochrome P450 3A5Chan, E.C.Y. ; New, L.S. ; Chua, T.B.; Yap, C.W. ; Ho, H.K. ; Nelson, S.D.
Nov-2008Investigation of the drug-drug interaction between α-lipoic acid and valproate via mitochondrial β-oxidationPhua, L.C.; New, L.S. ; Goh, C.W.; Neo, A.H.; Browne, E.R.; Chan, E.C.Y. 
1-Feb-2010Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicitySaha, S.; New, L.S. ; Ho, H.K. ; Chui, W.K. ; Chan, E.C.Y. 
Oct-2010Mechanism-based inactivation of cytochrome P450 3A4 by lapatinibTeng, W.C.; Oh, J.W.; New, L.S. ; Wahlin, M.D.; Nelson, S.D.; Ho, H.K. ; Chan, E.C.Y. 
Jun-2011Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinibTakakusa, H.; Wahlin, M.D.; Zhao, C.; Hanson, K.L.; New, L.S. ; Chan, E.C.Y. ; Nelson, S.D.
1-Apr-2011Metabolic profiling of 3-nitropropionic acid early-stage huntingtons disease rat model using gas chromatography time-of-flight mass spectrometryChang, K.L.; New, L.S. ; Mal, M.; Goh, C.W.; Aw, C.C.; Browne, E.R.; Chan, E.C.Y. 
4-Dec-2009Metabolic profiling of rat brain and cognitive behavioral tasks: Potential complementary strategies in preclinical cognition enhancement researchGoh, D.P.Q.; Neo, A.H.; Goh, C.W.; Aw, C.C.; New, L.S. ; Chen, W.S.; Atcha, Z.; Browne, E.R.; Chan, E.C.Y. 
2013Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicinNew, L.S. ; Lim, T.P.; Oh, J.W.; Cheah, G.J.S.; Kwa, A.L.; Chan, E.C.Y. 
Aug-2008Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726Seah, Q.M.; New, L.-S. ; Chan, E.C.Y. ; Boelsterli, U.A.
15-Feb-2009Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometryChan, E.C.Y. ; Lee, S.N. ; Chun, W.Y. ; Lin, T.G.
2007Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometryNew, L.-S. ; Saha, S.; Boelsterli, U.A. ; CHAN CHUN YONG,ERIC ; Ong, M.M.K.
2007Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometryNew, L.-S. ; Saha, S.; Ong, M.M.K.; Boelsterli, U.A.; Chan, E.C.Y. 
Dec-2011Preclinical metabolism and disposition of SB939 (pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokineticsJayaraman, R.; Reddy, V.P.; Pasha, M.K.; Wang, H.; Sangthongpitag, K.; Yeo, P.; Hu, C.Y.; Wu, X.; Xin, L.; Goh, E.; New, L.S. ; Ethirajulu, K.
28-Aug-2008Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imineTan, S.C.; New, L.S. ; Chan, E.C.Y. 
15-Dec-2012Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer propertiesSaha, S.; Chan, D.S.Z.; Lee, C.Y.; Wong, W.; New, L.S. ; Chui, W.K. ; Yap, C.W. ; Chan, E.C.Y. ; Ho, H.K. 
30-Oct-2011Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivationChan, C.Y.; New, L.S. ; Ho, H.K. ; Chan, E.C.Y. 
Jan-2014Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse modelBard-Chapeau, E.A.; Nguyen, A.-T.; Rust, A.G.; Sayadi, A.; Lee, P.; Chua, B.Q.; New, L.-S. ; De Jong, J.; Ward, J.M.; Chin, C.K.Y.; Chew, V.; Toh, H.C.; Abastado, J.-P.; Benoukraf, T. ; Soong, R.; Bard, F.A.; Dupuy, A.J.; Johnson, R.L.; Radda, G.K.; Chan, E.C.Y. ; Wessels, L.F.A.; Adams, D.J.; Jenkins, N.A.; Copeland, N.G.
1-May-2010Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginsengToh, D.-F. ; New, L.-S. ; Koh, H.-L. ; Chan, E.C.-Y. 
15-Jul-2009Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicityKashimshetty, R.; Desai, V.G.; Kale, V.M.; Lee, T.; Moland, C.L.; Branham, W.S.; New, L.S. ; Chan, E.C.Y. ; Younis, H.; Boelsterli, U.A.