Browsing by Author Sim Tiow Suan

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Issue DateTitleAuthor(s)
2005Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparumLiuh, L.G.; Sim, T.S. 
2010Characterization of Plasmodium falciparum co-chaperone p23: Its intrinsic chaperone activity and interaction with Hsp90Chua, C.-S.; Low, H.; Goo, K.-S. ; Sim, T.S. 
2001Cloning and sequence characterisation of falcipain-2 from Plasmodium falciparum Gombak A strain (Malaysia)Sim, T.-S. ; Loke, P. ; Singh, M. ; Lee, M.; Flotow, H.
2001Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585Soh, B.S.; Loke, P. ; Sim, T.-S. 
1995Coliphages as a rapid indicator of sequencing batch reactor (SBR) treatment performanceSim, T.S. ; Ng, W.J. ; Ong, S.L.. ; Ng, K.Y.; Ramasamay, M.; Tan, K.N.
2003Conserved structural modules and bonding networks in isopenicillin N synthase related non-haem iron-dependent oxygenases and oxidasesSim, J.; Wong, E.; Chin, H.S.; Sim, T.S. 
2001Construction of Streptomyces jumonjinensis isopenicillin N synthase double mutants, Ser119Ala/Glu120Gly and Thr308Ala/Thr309Val, overcomes insoluble expression in Escherichia coliWong, E.; Sim, J.; Sim, T.-S. 
2005Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymesGoh, S.L.; Goh, L.L.; Sim, T.S. 
2003Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificityChin, H.S.; Sim, J.; Seah, K.I.; Sim, T.S. 
2005Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: Implications for in vivo screens of inhibitorsChan, C.; Goh, L.L.; Sim, T.-S. 
2009Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin productionGoo, K.-S. ; Chua, C.-S.; Sim, T.-S. 
2008Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonolsChua, C.S.; Biermann, D.; Goo, K.S. ; Sim, T.-S. 
2005Endorsing functionality of Burkholderia pseudomallei glyoxylate cycle genes as anti-persistence drug screensLye, Y.M.; Chan, M. ; Sim, T.-S. 
2004Engineering recombinant Streptomyces coelicolor malate synthase with improved thermal properties by directed mutagenensisKoh, R. ; Goh, L.-L.; Sim, T.-S. 
2005Erratum: Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: Implications for in vivo screens of inhibitors (FEMS Microbiology Letters (2005) 249 (315-321) DOI: 10.1016/j.femsle.2005.06.024)Chan, C.; Goh, L.L.; Sim, T.-S. 
1-Dec-1997Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthaseLoke, P. ; Sim, J.; Sim, T.-S. 
12-Jan-1996Functional analysis of conserved histidine residues in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesisTan, D.S.H. ; Sim, T.-S. 
2004Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparumChan, M.; Sim, T.-S. 
Jan-2004Functional characterization of an alternative [lactate dehydrogenase-like] malate dehydrogenase in Plasmodium falciparumChan, M.; Sim, T.S. 
2004Functional characterization of an alternative [lactate dehydrogenase-like] malate dehydrogenase in Plasmodium falciparumChan, M.; Sim, T.S.