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Sim Tiow Suan
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Showing results 1 to 20 of 82
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Issue Date
Title
Author(s)
2004
A Complete Library of Amino Acid Alterations at N304 in Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Elucidates the Basis for Enhanced Penicillin Analogue Conversion
Chin, H.S.
;
Goo, K.S.
;
Sim, T.S.
2008
A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity
Kian, S.G.
;
Chun, S.C.
;
Sim, T.-S.
2006
A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization
Chan, M.
;
Tan, D.S.H.
;
Wong, S.-H.
;
Sim, T.-S.
11-Mar-1999
Amino acid substitutions affecting protein solubility: High level expression of Streptomyces clavuligerus isopenicillin N synthase in Escherichia coli
Sim, J.
;
Sim, T.-S.
1996
Ammonia removal from aquaculture water by means of fluidised technology
Ng, W.J.
;
Kho, K.
;
Ong, S.L.
;
Sim, T.S.
;
Ho, J.M.
1998
Analysis of a conserved arginine R281L in catalysis in Cephalosporium acremonium isopenicillin N synthase
Loke, P.
;
Sim, T.-S.
2009
Atypical caseinolytic protease homolog from Plasmodium falciparum possesses unusual substrate preference and a functional nuclear localization signal
Lin, W.
;
Chan, M.
;
Sim, T.-S.
2005
Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum
Liuh, L.G.
;
Sim, T.S.
2010
Characterization of Plasmodium falciparum co-chaperone p23: Its intrinsic chaperone activity and interaction with Hsp90
Chua, C.-S.
;
Low, H.
;
Goo, K.-S.
;
Sim, T.S.
2001
Cloning and sequence characterisation of falcipain-2 from Plasmodium falciparum Gombak A strain (Malaysia)
Sim, T.-S.
;
Loke, P.
;
Singh, M.
;
Lee, M.
;
Flotow, H.
2001
Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585
Soh, B.S.
;
Loke, P.
;
Sim, T.-S.
1995
Coliphages as a rapid indicator of sequencing batch reactor (SBR) treatment performance
Sim, T.S.
;
Ng, W.J.
;
Ong, S.L..
;
Ng, K.Y.
;
Ramasamay, M.
;
Tan, K.N.
2003
Conserved structural modules and bonding networks in isopenicillin N synthase related non-haem iron-dependent oxygenases and oxidases
Sim, J.
;
Wong, E.
;
Chin, H.S.
;
Sim, T.S.
2001
Construction of Streptomyces jumonjinensis isopenicillin N synthase double mutants, Ser119Ala/Glu120Gly and Thr308Ala/Thr309Val, overcomes insoluble expression in Escherichia coli
Wong, E.
;
Sim, J.
;
Sim, T.-S.
2005
Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes
Goh, S.L.
;
Goh, L.L.
;
Sim, T.S.
2003
Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity
Chin, H.S.
;
Sim, J.
;
Seah, K.I.
;
Sim, T.S.
2005
Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: Implications for in vivo screens of inhibitors
Chan, C.
;
Goh, L.L.
;
Sim, T.-S.
2009
Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production
Goo, K.-S.
;
Chua, C.-S.
;
Sim, T.-S.
2008
Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols
Chua, C.S.
;
Biermann, D.
;
Goo, K.S.
;
Sim, T.-S.
2005
Endorsing functionality of Burkholderia pseudomallei glyoxylate cycle genes as anti-persistence drug screens
Lye, Y.M.
;
Chan, M.
;
Sim, T.-S.