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SIR DAVID LANE
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Showing results 1 to 20 of 23
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Issue Date
Title
Author(s)
2017
A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53
Wong, J.H
;
Alfatah, M
;
Sin, M.F
;
Sim, H.M
;
Verma, C.S
;
Lane, D.P
;
Arumugam, P
2013
Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth
Wong, J.S
;
Warbrick, E
;
Vojtesk, B
;
Hill, J
;
Lane, D.P
2015
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays
Xiong Tan, B
;
Brown, C.J
;
Ferrer, F.J
;
Yuen, T.Y
;
Quah, S.T
;
Chan, B.H
;
Jansson, A.E
;
Teo, H.L
;
Nordlund, P
;
Lane, D.P
2018
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds M.J.G.W.
;
Pastor-Fernández A.
;
Popova G.
;
van Leeuwen I.M.M.
;
Eng K.E.
;
Drummond C.J.
;
Johansson L.
;
Svensson R.
;
Westwood N.J.
;
McCarthy A.R.
;
Tholander F.
;
Popa M.
;
Lane D.P.
;
McCormack E.
;
McInerney G.M.
;
Bhatia R.
;
Laín S.
2016
Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
Wei, S.J
;
Chee, S
;
Yurlova, L
;
Lane, D
;
Verma, C
;
Brown, C
;
Ghadessy, F
2016
Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design
Tan, Y.S
;
Reeks, J
;
Brown, C.J
;
Thean, D
;
Ferrer Gago, F.J
;
Yuen, T.Y
;
Goh, E.T.L
;
Lee, X.E.C
;
Jennings, C.E
;
Joseph, T.L
;
Lakshminarayanan, R
;
Lane, D.P
;
Noble, M.E.M
;
Verma, C.S
2017
Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
Yadahalli, S
;
Li, J
;
Lane, D.P
;
Gosavi, S
;
Verma, C.S
2010
Differences in the transactivation domains of p53 family members: A computational study
Mavinahalli, J.N
;
Madhumalar, A
;
Beuerman, R.W
;
Lane, D.P
;
Verma, C
2017
Enhancing specific disruption of intracellular protein complexes by hydrocarbon stapled peptides using lipid based delivery
Thean, D
;
Ebo, J.S
;
Luxton, T
;
Lee, X.C
;
Yuen, T.Y
;
Ferrer, F.J
;
Johannes, C.W
;
Lane, D.P
;
Brown, C.J
2010
Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy.
Rao, B
;
van Leeuwen, I.M.
;
Higgins, M.
;
Campbel, J.
;
Thompson, A.M.
;
Lane, D.P.
;
Lain, S.
2016
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens
Siau, J.W
;
Coffill, C.R
;
Zhang, W.V
;
Tan, Y.S
;
Hundt, J
;
Lane, D
;
Verma, C
;
Ghadessy, F
2014
High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
Tan, B.X
;
Khoo, K.H
;
Lim, T.M
;
Lane, D.P
2016
Long range recognition and selection in IDPs: The interactions of the C-terminus of p53
Kannan, S
;
Lane, D.P
;
Verma, C.S
2008
MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism
Paulin, F.E.M
;
O'Neill, M
;
McGregor, G
;
Cassidy, A
;
Ashfield, A
;
Ali, C.W
;
Munro, A.J
;
Baker, L
;
Purdie, C.A
;
Lane, D.P
;
Thompson, A.M
3-Dec-2009
Modulation of p53 binding to MDM2: Computational studies reveal important roles of Tyr100
Dastidar, S.G.
;
Lane, D.P.
;
Verma, C.S.
2015
Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
Goh, A.M
;
Xue, Y
;
Leushacke, M
;
Li, L
;
Wong, J.S
;
Chiam, P.C
;
Binte Rahmat, S.A
;
Mann, M.B
;
Mann, K.M
;
Barker, N
;
Lozano, G
;
Terzian, T
;
Lane, D.P
2011
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
Neilsen, P.M
;
Noll, J.E
;
Suetani, R.J
;
Schulz, R.B
;
Al-Ejeh, F
;
Evdokiou, A
;
Lane, D.P
;
Callen, D.F
2011
P53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
Bourdon, J.-C
;
Khoury, M.P
;
Diot, A
;
Baker, L
;
Fernandes, K
;
Aoubala, M
;
Quinlan, P
;
Purdie, C.A
;
Jordan, L.B
;
Prats, A
;
Lane, D.P
;
Thompson, A.M
2017
Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53
Chan, J.V
;
Koh, D.X.P
;
Liu, Y
;
Joseph, T.L
;
Lane, D.P
;
Verma, C.S
;
Tan, Y.S
2008
Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin
Avery-Kiejda, K.A
;
Xu, D.Z
;
Adams, L.J
;
Scott, R.J
;
Vojtesek, B
;
Lane, D.P
;
Hersey, P