Browsing by Author ALAN PREM KUMAR

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Issue DateTitleAuthor(s)
2013An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteinsSubramaniam, A.; Loo, S.Y.; Rajendran, P.; Manu, K.A. ; Perumal, E.; Li, F.; Shanmugam, M.K. ; Siveen, K.S.; Park, J.-I.; Ahn, K.S.; Hui, K.M.; Kumar, A.P. ; Sethi, G.
1-Sep-2011Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathwayWoo, C.C.; Loo, S.Y.; Gee, V.; Yap, C.W. ; Sethi, G.; Kumar, A.P. ; Benny Tan, K.H.
15-Nov-2010Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cellsChua, A.W.L.; Hay, H.S. ; Rajendran, P.; Shanmugam, M.K. ; Li, F.; Bist, P.; Koay, E.S.C.; Lim, L.H.K.; Kumar, A.P. ; Sethi, G.
Nov-2011Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cellsKannaiyan, R.; Hay, H.S. ; Rajendran, P.; Li, F.; Shanmugam, M.K. ; Vali, S.; Abbasi, T.; Kapoor, S.; Sharma, A.; Kumar, A.P. ; Chng, W.-J.; Sethi, G.
Oct-2011Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathwaysKannaiyan, R.; Manu, K.A. ; Chen, L.; Li, F.; Rajendran, P.; Subramaniam, A.; Lam, P.; Kumar, A.P. ; Sethi, G.
Apr-2012Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In VivoRajendran, P.; Li, F.; Shanmugam, M.K. ; Kannaiyan, R.; Goh, J.; Wong, K. ; Wang, W.; Khin, E.; Tergaonkar, V.; Kumar, A. ; Luk, J.M.; Sethi, G.
2009Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of humanVenkatachalam, G. ; Clement, M.V. ; Kumar, A.P. ; Yue, L.S.; Pervaiz, S. ; Sakharkar, M.K.
2009Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of humanVenkatachalam G.; Kumar A.P. ; Yue L.S. ; Pervaiz S. ; Clement M.V. ; Sakharkar M.K. 
Apr-2013Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPasesZhu, Y.; Casey, P.J. ; Kumar, A.P. ; Pervaiz, S.
2009Deformability study of breast cancer cells using microfluidicsHou, H.W.; Lim, C.T. ; Li, Q.S.; Lee, G.Y.H. ; Kumar, A.P. ; Ong, C.N. 
Oct-2013Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3Subramaniam, A.; Shanmugam, M.K. ; Ong, T.H.; Li, F.; Perumal, E.; Chen, L.; Vali, S.; Abbasi, T.; Kapoor, S.; Ahn, K.S.; Kumar, A.P. ; Hui, K.M.; Sethi, G.
5-Mar-2013Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular CarcinomaManu, K.A. ; Shanmugam, M.K. ; Ong, T.H.; Subramaniam, A.; Siveen, K.S.; Perumal, E.; Samy, R.P. ; Bist, P.; Lim, L.H.K.; Kumar, A.P. ; Hui, K.M.; Sethi, G.
15-Apr-2012First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathwayManu, K.A. ; Shanmugam, M.K. ; Ramachandran, L.; Li, F.; Fong, C.W.; Kumar, A.P. ; Tan, P. ; Sethi, G.
29-Jun-2016Functional characterization of selective exosite-binding inhibitors of Matrix metalloproteinase-13 (MMP-13) – experimental validation in human breast and colon cancerKodappully Siveen ; Tuan Zea Tan ; Jean-Paul Thierry ; Alan Prem Kumar ; Gautam Sethi ; Kunchithapadam Swaminathan 
Aug-2013Garcinol, a polyisoprenylated benzophenone modulates multiple proinfl ammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinomaLi, F.; Shanmugam, M.K. ; Chen, L.; Chatterjee, S.; Basha, J.; Kumar, A.P. ; Kundu, T.K.; Sethi, G.
21-Aug-2012Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascadeZhuo, J.; Tan, E.H.; Yan, B.; Tochhawng, L.; Jayapal, M.; Koh, S.; Tay, H.K.; Maciver, S.K.; Hooi, S.C.; Salto-Tellez, M. ; Kumar, A.P. ; Goh, Y.C.; Lim, Y.C.; Yap, C.T.
May-2012Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1Rajendran, P.; Li, F.; Shanmugam, M.K. ; Vali, S.; Abbasi, T.; Kapoor, S.; Ahn, K.S.; Kumar, A.P. ; Sethi, G.
2010Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cellsTan, S.M.-L.; Li, F. ; Rajendran, P. ; Kumar, A.P. ; Sethi, G. ; Hui, K.M.
1-Oct-2011Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate modelShanmugam, M.K. ; Manu, K.A. ; Ong, T.H.; Ramachandran, L.; Surana, R.; Bist, P.; Lim, L.H.K.; Prem Kumar, A. ; Hui, K.M.; Sethi, G.
2-Nov-2012Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancerRamachandran, L.; Manu, K.A. ; Shanmugam, M.K. ; Li, F.; Siveen, K.S.; Vali, S.; Kapoor, S.; Abbasi, T.; Surana, R.; Smoot, D.T.; Ashktorab, H.; Tan, P. ; Ahn, K.S.; Yap, C.W. ; Kumar, A.P. ; Sethi, G.