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Browsing by Author ALAN PREM KUMAR

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Issue DateTitleAuthor(s)
2013An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteinsSubramaniam, A.; Loo, S.Y.; Rajendran, P.; Manu, K.A. ; Perumal, E.; Li, F.; Shanmugam, M.K. ; Siveen, K.S.; Park, J.-I.; Ahn, K.S.; Hui, K.M.; Kumar, A.P. ; Sethi, G.
1-Sep-2011Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathwayWoo, C.C.; Loo, S.Y.; Gee, V.; Yap, C.W. ; Sethi, G.; Kumar, A.P. ; Benny Tan, K.H.
15-Nov-2010Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cellsChua, A.W.L.; Hay, H.S. ; Rajendran, P.; Shanmugam, M.K. ; Li, F.; Bist, P.; Koay, E.S.C.; Lim, L.H.K.; Kumar, A.P. ; Sethi, G.
Dec-2019c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progressionSim, Wen Jing ; Iyengar, Prasanna Vasudevan ; Lama, Dilraj; Lui, Sarah Kit Leng ; Ng, Hsien Chun ; Haviv-Shapira, Lior; Domany, Eytan; Kappei, Dennis ; Tan, Tuan Zea ; Saie, Azad; Jaynes, Patrick William ; Verma, Chandra Shekhar ; Kumar, Alan Prem ; Rouanne, Mathieu; Ha, Hong Koo; Radulescu, Camelia; ten Dijke, Peter; Eichhorn, Pieter Johan Adam ; Thiery, Jean Paul 
Nov-2011Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cellsKannaiyan, R.; Hay, H.S. ; Rajendran, P.; Li, F.; Shanmugam, M.K. ; Vali, S.; Abbasi, T.; Kapoor, S.; Sharma, A.; Kumar, A.P. ; Chng, W.-J.; Sethi, G.
Oct-2011Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathwaysKannaiyan, R.; Manu, K.A. ; Chen, L.; Li, F.; Rajendran, P.; Subramaniam, A.; Lam, P.; Kumar, A.P. ; Sethi, G.
Apr-2012Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In VivoRajendran, P.; Li, F.; Shanmugam, M.K. ; Kannaiyan, R.; Goh, J.; Wong, K. ; Wang, W.; Khin, E.; Tergaonkar, V.; Kumar, A. ; Luk, J.M.; Sethi, G.
2009Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of humanVenkatachalam, G. ; Clement, M.V. ; Kumar, A.P. ; Yue, L.S.; Pervaiz, S. ; Sakharkar, M.K.
2009Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of humanVenkatachalam G.; Kumar A.P. ; Yue L.S. ; Pervaiz S. ; Clement M.V. ; Sakharkar M.K. 
18-Jan-2019Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic PerspectiveOng, Mei Shan; Deng, Shuo ; Halim, Clarissa Esmeralda ; Cai, Wanpei ; Tan, Tuan Zea ; Huang, Ruby Yun-Ju ; Sethi, Gautam ; Hooi, Shing Chuan ; Kumar, Alan Prem ; Yap, Celestial T 
Apr-2013Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPasesZhu, Y.; Casey, P.J. ; Kumar, A.P. ; Pervaiz, S.
2009Deformability study of breast cancer cells using microfluidicsHou, H.W.; Lim, C.T. ; Li, Q.S.; Lee, G.Y.H. ; Kumar, A.P. ; Ong, C.N. 
Oct-2013Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3Subramaniam, A.; Shanmugam, M.K. ; Ong, T.H.; Li, F.; Perumal, E.; Chen, L.; Vali, S.; Abbasi, T.; Kapoor, S.; Ahn, K.S.; Kumar, A.P. ; Hui, K.M.; Sethi, G.
5-Mar-2013Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular CarcinomaManu, K.A. ; Shanmugam, M.K. ; Ong, T.H.; Subramaniam, A.; Siveen, K.S.; Perumal, E.; Samy, R.P. ; Bist, P.; Lim, L.H.K.; Kumar, A.P. ; Hui, K.M.; Sethi, G.
15-Apr-2012First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathwayManu, K.A. ; Shanmugam, M.K. ; Ramachandran, L.; Li, F.; Fong, C.W.; Kumar, A.P. ; Tan, P. ; Sethi, G.
29-Jun-2016Functional characterization of selective exosite-binding inhibitors of Matrix metalloproteinase-13 (MMP-13) – experimental validation in human breast and colon cancerKodappully Siveen ; Tuan Zea Tan ; Jean-Paul Thierry ; Alan Prem Kumar ; Gautam Sethi ; Kunchithapadam Swaminathan 
Aug-2013Garcinol, a polyisoprenylated benzophenone modulates multiple proinfl ammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinomaLi, F.; Shanmugam, M.K. ; Chen, L.; Chatterjee, S.; Basha, J.; Kumar, A.P. ; Kundu, T.K.; Sethi, G.
21-Aug-2012Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascadeZhuo, J.; Tan, E.H.; Yan, B.; Tochhawng, L.; Jayapal, M.; Koh, S.; Tay, H.K.; Maciver, S.K.; Hooi, S.C.; Salto-Tellez, M. ; Kumar, A.P. ; Goh, Y.C.; Lim, Y.C.; Yap, C.T.
3-May-2016Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinomaHuang, Baohua ; DENG SHUO ; LOO SER YUE ; ARPITA DATTA ; YAP YAN LIN ; Yan, Benedict; OOI CHIA HUEY ; DINH THUY DUONG ; ZHUO JINGLI ; LALCHHANDAMI TOCHHAWNG ; SUMA GOPINADHAN ; Jegadeesan, Tamilarasi; TAN BOON OOI,PATRICK ; SALTO-TELLEZ,MANUEL ; YONG WEI PENG ; SOONG CHUAN TECK,RICHIE ; YEOH KHAY GUAN ; GOH YAW CHONG ; PETER EDWARD LOBIE ; YANG HE ; ALAN PREM KUMAR ; Maciver, Sutherland K; SO BOK YAN,JIMMY ; Yap Suen Mei,Celestial Therese 
May-2012Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1Rajendran, P.; Li, F.; Shanmugam, M.K. ; Vali, S.; Abbasi, T.; Kapoor, S.; Ahn, K.S.; Kumar, A.P. ; Sethi, G.
Showing results 1 to 20 of 55  next >