Please use this identifier to cite or link to this item: https://doi.org/10.4161/cc.22772
Title: A role for polyamine regulators in ESC self-renewal
Authors: Zhao, T.
Goh, K.J.
Ng, H.H. 
Vardy, L.A.
Keywords: Amd1
Embryonic stem cells
iPSC
Odc1
Polyamines
Spermine
Issue Date: 15-Dec-2012
Source: Zhao, T., Goh, K.J., Ng, H.H., Vardy, L.A. (2012-12-15). A role for polyamine regulators in ESC self-renewal. Cell Cycle 11 (24) : 4517-4523. ScholarBank@NUS Repository. https://doi.org/10.4161/cc.22772
Abstract: Embryonic stem cells (ESCs) depend on extensive regulatory networks to coordinate their self-renewal and differentiation. The polyamine pathway regulator AMD1 was recently implicated in ESC self-renewal and directed differentiation of ESCs to neural precursor cells (NPCs). The polyamines spermine and spermidine are essential for a wide range of biological processes, and their levels are tightly regulated. Here, we review the polyamine pathway and discuss how it can impact polyamine levels, cellular methylation and hypusinated EIF5A levels. We discuss how it could feed into regulation of ESC self-renewal and directed differentiation. We show that in addition to AMD1, a second rate-limiting enzyme in the polyamine pathway, ODC1, can also promote ESC self-renewal, and that both Amd1 and Odc1 can partially substitute for Myc during cellular reprogramming. We propose that both Amd1 and Odc1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal. 2012; © 2012 Landes Bioscience.
Source Title: Cell Cycle
URI: http://scholarbank.nus.edu.sg/handle/10635/99959
ISSN: 15384101
DOI: 10.4161/cc.22772
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