Please use this identifier to cite or link to this item: https://doi.org/10.1038/nchembio.1225
Title: A cell-cell communication signal integrates quorum sensing and stress response
Authors: Lee, J.
Wu, J.
Deng, Y.
Wang, J.
Wang, C.
Wang, J.
Chang, C.
Dong, Y.
Williams, P.
Zhang, L.-H. 
Issue Date: May-2013
Citation: Lee, J., Wu, J., Deng, Y., Wang, J., Wang, C., Wang, J., Chang, C., Dong, Y., Williams, P., Zhang, L.-H. (2013-05). A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology 9 (5) : 339-343. ScholarBank@NUS Repository. https://doi.org/10.1038/nchembio.1225
Abstract: Pseudomonas aeruginosa uses a hierarchical quorum sensing (QS) network consisting of las, pqs and rhl regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central las system. This motivated us to search for a mechanism that may functionally substitute las. Here we report identification of a new QS signal, IQS. Disruption of IQS biosynthesis paralyzes the pqs and rhl QS systems and attenuates bacterial virulence. Production of IQS is tightly controlled by las under normal culture conditions but is also activated by phosphate limitation, a common stressor that bacteria encounter during infections. Thus, these results have established an integrated QS system that connects the central las system and phosphate-stress response mechanism to the downstream pqs and rhl regulatory systems. Our discovery highlights the complexity of QS signaling systems and extends the gamut of QS and stress-response mechanisms. © 2013 Nature America, Inc.
Source Title: Nature Chemical Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/99799
ISSN: 15524450
DOI: 10.1038/nchembio.1225
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

104
checked on Sep 19, 2018

WEB OF SCIENCETM
Citations

98
checked on Sep 3, 2018

Page view(s)

91
checked on Sep 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.