Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0168-583X(03)01062-0
Title: Trace elemental distributions in induced atherosclerotic lesions using nuclear microscopy
Authors: Minqin, R. 
Watt, F. 
Huat, B.T.K.
Halliwell, B.
Keywords: Atherosclerosis
Desferal
Iron
Iron chelation
Nuclear Microscopy
Trace element distributions
Issue Date: Sep-2003
Source: Minqin, R., Watt, F., Huat, B.T.K., Halliwell, B. (2003-09). Trace elemental distributions in induced atherosclerotic lesions using nuclear microscopy. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 210 : 336-342. ScholarBank@NUS Repository. https://doi.org/10.1016/S0168-583X(03)01062-0
Abstract: Nuclear Microscopy, using the combination of scanning transmission ion microscopy, Rutherford backscattering spectrometry and proton induced X-ray emission has the ability to map and accurately quantify localised trace element levels in newly formed atherosclerotic lesions. In this study, New Zealand white rabbits fed on a high cholesterol diet were divided into two groups. One test group was treated with an iron chelating agent desferal, and the second group served as a control model. Tissue sections were taken from the aortic arch, flash frozen and air-dried, and scanned using the nuclear microscope of the Research Centre for Nuclear Microscopy, NUS. Results of this experiment, although not definitive (p=0.07) indicated that during the treatment with desferal, there was a trend for lesion development to be slowed down. However, analysis of atherosclerotic lesions both from the test and control groups showed that iron concentrations within the lesions exhibit a high degree of correlation with the depth of the lesion in the artery wall, whereas zinc is observed to be anti-correlated to the size of the lesion area. This investigation implies that the observed high iron levels, which can lead to increased free radical damage, may cause premature or accelerated arterial damage. © 2003 Elsevier B.V. All rights reserved.
Source Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
URI: http://scholarbank.nus.edu.sg/handle/10635/98943
ISSN: 0168583X
DOI: 10.1016/S0168-583X(03)01062-0
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