Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2012.07.008
Title: Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice
Authors: Kumar, S.D.
Vijaya, M.
Samy, R.P. 
Dheen, S.T.
Ren, M. 
Watt, F. 
Kang, Y.J.
Bay, B.-H.
Tay, S.S.W.
Keywords: Antioxidant
Cardiac malformations
Embryos
Heart
Maternal diabetes
Metallothionein
Mice
Nuclear microscopy
Oxidative stress
Zinc
Issue Date: 15-Oct-2012
Source: Kumar, S.D., Vijaya, M., Samy, R.P., Dheen, S.T., Ren, M., Watt, F., Kang, Y.J., Bay, B.-H., Tay, S.S.W. (2012-10-15). Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice. Free Radical Biology and Medicine 53 (8) : 1595-1606. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2012.07.008
Abstract: Oxidative stress induced by maternal diabetes plays an important role in the development of cardiac malformations. Zinc (Zn) supplementation of animals and humans has been shown to ameliorate oxidative stress induced by diabetic cardiomyopathy. However, the role of Zn in the prevention of oxidative stress induced by diabetic cardiac embryopathy remains unknown. We analyzed the preventive role of Zn in diabetic cardiac embryopathy by both in vivo and in vitro studies. In vivo study revealed a significant decrease in lipid peroxidation, superoxide ions, and oxidized glutathione and an increase in reduced glutathione, nitric oxide, and superoxide dismutase in the developing heart at embryonic days (E) 13.5 and 15.5 in the Zn-supplemented diabetic group when compared to the diabetic group. In addition, significantly down-regulated protein and mRNA expression of metallothionein (MT) in the developing heart of embryos from diabetic group was rescued by Zn supplement. Further, the nuclear microscopy results showed that trace elements such as phosphorus, calcium, and Zn levels were significantly increased (P
Source Title: Free Radical Biology and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/98616
ISSN: 08915849
DOI: 10.1016/j.freeradbiomed.2012.07.008
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

28
checked on Feb 22, 2018

WEB OF SCIENCETM
Citations

27
checked on Jan 22, 2018

Page view(s)

27
checked on Feb 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.