Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(99)01199-0
Title: The onset of atherosclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion
Authors: Ponraj, D.
Makjanic, J. 
Thong, P.S.P. 
Tan, B.K.H.
Watt, F. 
Keywords: Atherosclerosis
Iron
Nuclear microscopy
Oxidative stress
Issue Date: 8-Oct-1999
Citation: Ponraj, D., Makjanic, J., Thong, P.S.P., Tan, B.K.H., Watt, F. (1999-10-08). The onset of atherosclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion. FEBS Letters 459 (2) : 218-222. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01199-0
Abstract: The theory that iron may play a significant role in atherogenesis by promoting the formation of free radicals is controversial. Previous results using the new technique of nuclear microscopy showed a seven-fold increase in iron concentrations within newly formed atherosclerotic lesions in hypercholesterolemic rabbits compared to healthy artery tissue. In a follow- up time sequence study described here, we show that iron accumulation occurs at the onset of lesion formation. In addition, weekly bleeding decreases the iron uptake into the artery wall and delays the onset of atherogenesis. These results provide direct evidence for a key role of iron in initiating atherogenesis.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/98304
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)01199-0
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