Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.aca.2007.05.047
Title: Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites
Authors: Cui, H.-F. 
Ye, J.-S. 
Zhang, W.-D.
Li, C.-M.
Luong, J.H.T.
Sheu, F.-S. 
Keywords: Amperometry
Carbon nanotube
Glucose detection
Interferences
Nafion
Platinum-lead nanoparticle
Issue Date: 2-Jul-2007
Citation: Cui, H.-F., Ye, J.-S., Zhang, W.-D., Li, C.-M., Luong, J.H.T., Sheu, F.-S. (2007-07-02). Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites. Analytica Chimica Acta 594 (2) : 175-183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.aca.2007.05.047
Abstract: Electrodeposition of Pt-Pb nanoparticles (PtPbNPs) to multi-walled carbon nanotubes (MWCNTs) resulted in a stable PtPbNP/MWCNT nanocomposite with high electrocatalytic activity to glucose oxidation in either neutral or alkaline medium. More importantly, the nanocomposite electrode with a slight modification exhibited high sensitivity, high selectivity, and low detection limit in amperometric glucose sensing at physiological neutral pH (poised at a negative potential). At +0.30 V in neutral solution, the nanocomposite electrode exhibited linearity up to 11 mM of glucose with a sensitivity of 17.8 μA cm-2 mM-1 and a detection limit of 1.8 μM (S/N = 3). Electroactive ascorbic acid (0.1 mM), uric acid (0.1 mM) and fructose (0.3 mM) invoked only 23%, 14% and 9%, respectively, of the current response obtained for 3 mM glucose. At -0.15 V in neutral solution, the electrode responded linearly to glucose up to 5 mM with a detection limit of 0.16 mM (S/N = 3) and detection sensitivity of ∼18 μA cm-2 mM-1. At this negative potential, ascorbic acid, uric acid, and fructose were not electroactive, therefore, not interfering with glucose sensing. Modification of the nanocomposite electrode with Nafion coating followed by electrodeposition of a second layer of PtPbNPs on the Nafion coated PtPbNP/MWCNT nanocomposite produced a glucose sensor (poised at -0.15 V) with a lower detection limit (7.0 μM at S/N = 3) and comparable sensitivity, selectivity and linearity compared to the PtPbNP/MWCNT nanocomposite. The Nafion coating lowered the detection limit by reducing the background noise, while the second layer of PtPbNPs restored the sensitivity to the level before Nafion coating. © 2007 Elsevier B.V. All rights reserved.
Source Title: Analytica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/97878
ISSN: 00032670
DOI: 10.1016/j.aca.2007.05.047
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

196
checked on Dec 4, 2018

WEB OF SCIENCETM
Citations

189
checked on Dec 4, 2018

Page view(s)

41
checked on Nov 16, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.