Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.2976140
Title: Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis
Authors: Kho, K.W.
Qing, K.Z.M.
Shen, Z.X.
Ahmad, I.B.
Lim, S.S.C.
Mhaisalkar, S.
White, T.J.
Watt, F. 
Soo, K.C.
Olivo, M. 
Keywords: biofluids
ionic strength
microfluidics
surface enhanced Raman spectroscopy
urine
Issue Date: 2008
Citation: Kho, K.W., Qing, K.Z.M., Shen, Z.X., Ahmad, I.B., Lim, S.S.C., Mhaisalkar, S., White, T.J., Watt, F., Soo, K.C., Olivo, M. (2008). Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis. Journal of Biomedical Optics 13 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.2976140
Abstract: The use of microfluidics for biofluid analysis offers a cheaper alternative to conventional techniques in disease diagnosis. However, traditional microfluidics design may be complicated by the need to incorporate separation elements into the system in order to facilitate specific molecular detection. Alternatively, an optical technique known as surface-enhanced Raman spectroscopy (SERS) may be used to enable identification of analyte molecules directly from a complex sample. This will not only simplify design but also reduce overall cost. The concept of SERS-based microfluidics is however not new and has been demonstrated previously by mixing SERS-active metal nanoparticles with a model sample, in situ, within the microchannel. Although the SERS reproducibility of these systems was shown to be acceptable, it is, however, not stable toward variations in the salt content of the sample, as will be shown in this study. We have proposed a microfluidics design whereby periodic SERS-active metal nanostructures are fabricated directly into the microchannel via a simple method of spin coating. Using artificial as well as human urine samples, we show that the current microfluidics is more stable toward variations in the sample's ionic strength. © 2008 Society of Photo-Optical Instrumentation Engineers.
Source Title: Journal of Biomedical Optics
URI: http://scholarbank.nus.edu.sg/handle/10635/97568
ISSN: 10833668
DOI: 10.1117/1.2976140
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Jul 13, 2018

WEB OF SCIENCETM
Citations

19
checked on Jun 6, 2018

Page view(s)

36
checked on Jun 1, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.