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|Title:||Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing|
|Citation:||Lim, C.J., Lee, S.Y., Kenney, L.J., Yan, J. (2012). Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing. Scientific Reports 2 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep00509|
|Abstract:||H-NS is an abundant nucleoid-associated protein in bacteria that globally silences genes, including horizontally-acquired genes related to pathogenesis. Although it has been shown that H-NS has multiple modes of DNA-binding, which mode is employed in gene silencing is still unclear. Here, we report that in H-NS mutants that are unable to silence genes, are unable to form a rigid H-NS nucleoprotein filament. These results indicate that the H-NS nucleoprotein filament is crucial for its gene silencing function, and serves as the fundamental structural basis for gene silencing by H-NS and likely other H-NS-like bacterial proteins.|
|Source Title:||Scientific Reports|
|Appears in Collections:||Staff Publications|
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