Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0032953
Title: MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization
Authors: Zhang, C.
Liu, Y.
Gilthorpe, J.
van der Maarel, J.R.C. 
Issue Date: 22-Mar-2012
Source: Zhang, C., Liu, Y., Gilthorpe, J., van der Maarel, J.R.C. (2012-03-22). MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization. PLoS ONE 7 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0032953
Abstract: Increasing evidence supports the contribution of local inflammation to the development of Alzheimer's disease (AD) pathology, although the precise mechanisms are not clear. In this study, we demonstrate that the pro-inflammatory protein S100A9 interacts with the Aβ1-40 peptide and promotes the formation of fibrillar β-amyloid structures. This interaction also results in reduced S100A9 cytotoxicity by the binding of S100A9 toxic species to Aβ1-40 amyloid structures. These results suggest that secretion of S100A9 during inflammation promotes the formation of amyloid plaques. By acting as a sink for toxic species, plaque formation may be the result of a protective response within the brain of AD patients, in part mediated by S100A9. © 2012 Zhang et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/97264
ISSN: 19326203
DOI: 10.1371/journal.pone.0032953
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