Please use this identifier to cite or link to this item:
|Title:||Impact of DNA twist accumulation on progressive helical wrapping of torsionally constrained DNA|
|Citation:||Li, W., Wang, P.-Y., Yan, J., Li, M. (2012-11-20). Impact of DNA twist accumulation on progressive helical wrapping of torsionally constrained DNA. Physical Review Letters 109 (21) : -. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevLett.109.218102|
|Abstract:||DNA wrapping is an important mechanism for chromosomal DNA packaging in cells and viruses. Previous studies of DNA wrapping have been performed mostly on torsionally unconstrained DNA, while invivo DNA is often under torsional constraint. In this study, we extend a previously proposed theoretical model for wrapping of torsionally unconstrained DNA to a new model including the contribution of DNA twist energy, which influences DNA wrapping drastically. In particular, due to accumulation of twist energy during DNA wrapping, it predicts a finite amount of DNA that can be wrapped on a helical spool. The predictions of the new model are tested by single-molecule study of DNA wrapping under torsional constraint using magnetic tweezers. The theoretical predictions and the experimental results are consistent with each other and their implications are discussed. © 2012 American Physical Society.|
|Source Title:||Physical Review Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 22, 2018
WEB OF SCIENCETM
checked on Sep 12, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.