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|Title:||Growth of osteoblasts on lithographically modified surfaces|
Sagari A.R., A.
van Kan, J.A.
Proton beam writing
|Citation:||Gorelick, S., Rahkila, P., Sagari A.R., A., Sajavaara, T., Cheng, S., Karlsson, L.B., van Kan, J.A., Whitlow, H.J. (2007-07). Growth of osteoblasts on lithographically modified surfaces. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 260 (1) : 130-135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nimb.2007.02.008|
|Abstract:||Here we report about preliminary investigations on developing substrates for culturing osteoblasts, the cells responsible for production of mineralised bone, by lithographically modifying the surfaces of several materials. The proton beam writing system at the National University of Singapore was used to fabricate high aspect ratio structures in PMMA, while two-dimensional low aspect ratio structures were fabricated using conventional electron beam lithography (EBL) and UV lithography (UVL) in SU-8. It was found that oxygen plasma treatment of structured SU-8 surfaces changed the surface layer and significantly improved cell attachment and proliferation. Cells grown on patterned thick PMMA exhibit a remarkable geometry-dependent behaviour. © 2007 Elsevier B.V. All rights reserved.|
|Source Title:||Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms|
|Appears in Collections:||Staff Publications|
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