Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nimb.2007.02.008
Title: Growth of osteoblasts on lithographically modified surfaces
Authors: Gorelick, S.
Rahkila, P.
Sagari A.R., A.
Sajavaara, T.
Cheng, S.
Karlsson, L.B.
van Kan, J.A. 
Whitlow, H.J.
Keywords: Bone
Cell growth
Ion-sputtering
Osteoblast
PMMA
Proton beam writing
SU-8
Surface treatment
Issue Date: Jul-2007
Citation: Gorelick, S., Rahkila, P., Sagari A.R., A., Sajavaara, T., Cheng, S., Karlsson, L.B., van Kan, J.A., Whitlow, H.J. (2007-07). Growth of osteoblasts on lithographically modified surfaces. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 260 (1) : 130-135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nimb.2007.02.008
Abstract: Here we report about preliminary investigations on developing substrates for culturing osteoblasts, the cells responsible for production of mineralised bone, by lithographically modifying the surfaces of several materials. The proton beam writing system at the National University of Singapore was used to fabricate high aspect ratio structures in PMMA, while two-dimensional low aspect ratio structures were fabricated using conventional electron beam lithography (EBL) and UV lithography (UVL) in SU-8. It was found that oxygen plasma treatment of structured SU-8 surfaces changed the surface layer and significantly improved cell attachment and proliferation. Cells grown on patterned thick PMMA exhibit a remarkable geometry-dependent behaviour. © 2007 Elsevier B.V. All rights reserved.
Source Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
URI: http://scholarbank.nus.edu.sg/handle/10635/96758
ISSN: 0168583X
DOI: 10.1016/j.nimb.2007.02.008
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