Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/96439
Title: Elemental changes in atherosclerotic lesions using nuclear microscopy.
Authors: Thong, P.S. 
Selley, M.
Watt, F. 
Issue Date: Feb-1996
Source: Thong, P.S.,Selley, M.,Watt, F. (1996-02). Elemental changes in atherosclerotic lesions using nuclear microscopy.. Cellular and molecular biology (Noisy-le-Grand, France) 42 (1) : 103-110. ScholarBank@NUS Repository.
Abstract: The roles of iron and other trace metals in the aetiology of heart and brain diseases has been a subject of keen research because of the ability of metal ions to participate in reactions involving free radicals, which have been implicated in many of these diseases. Unstained freeze dried tissue sections from the aorta of New Zealand white rabbits fed with a 1% cholesterol diet for 12 weeks were scanned with a 2 MeV proton beam using the National University of Singapore nuclear microscope facility. Results from 6 test and 4 control rabbits show that there is an average of seven-fold increase in iron and an average of nearly two-fold increase in phosphorus in the atherosclerotic lesion compared with healthy tissue. The increase in iron adds weight to the hypothesis that iron-catalyzed free radical reactions may be associated with the development of atherosclerosis. A depletion of other elements analyzed was seen in the lesion. Elemental mapping also showed the occurrence of granules rich in sodium, chlorine and potassium at the interface between lesioned and non-lesioned tissue.
Source Title: Cellular and molecular biology (Noisy-le-Grand, France)
URI: http://scholarbank.nus.edu.sg/handle/10635/96439
ISSN: 01455680
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

15
checked on Jan 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.