Please use this identifier to cite or link to this item:
|Title:||Effects of kink and flexible hinge defects on mechanical responses of short double-stranded DNA molecules|
|Authors:||Chen, H. |
|Source:||Chen, H., Yan, J. (2008-04-15). Effects of kink and flexible hinge defects on mechanical responses of short double-stranded DNA molecules. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 77 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevE.77.041907|
|Abstract:||We predict various detectable mechanical responses to the presence of local DNA defects which are defined as short DNA segments exhibiting mechanical properties obviously different from the 50 nm persistence length based semiflexible polymer model. The defects discussed are kinks and flexible hinges either permanently fixed on DNA or thermally excited. Their effects on extension shift, the effective persistence length, the end-to-end distance distribution, and the cyclization probability are computed using a transfer-matrix method. Our predictions will be useful in future experimental designs to study DNA nicks or mismatch base pairs, mechanics of specific DNA sequences, and specific DNA-protein interaction using magnetic tweezer, fluorescence resonance energy transfer, plasmon resonance techniques, and the traditional biochemistry cyclization probability measurements. © 2008 The American Physical Society.|
|Source Title:||Physical Review E - Statistical, Nonlinear, and Soft Matter Physics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 7, 2018
WEB OF SCIENCETM
checked on Feb 5, 2018
checked on Mar 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.