Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nimb.2009.03.063
Title: Angular and lateral spreading of ion beams in biomedical nuclear microscopy
Authors: Whitlow, H.J.
Ren, M. 
van Kan, J.A. 
Osipowicz, T. 
Watt, F. 
Keywords: Biomedical imaging
Multiple scattering
Nuclear microscopy
PIXE
STIM
Issue Date: 15-Jun-2009
Citation: Whitlow, H.J., Ren, M., van Kan, J.A., Osipowicz, T., Watt, F. (2009-06-15). Angular and lateral spreading of ion beams in biomedical nuclear microscopy. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 267 (12-13) : 2153-2156. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nimb.2009.03.063
Abstract: Nuclear scattering from target atoms gives rise to a spatial broadening of energetic ion beams penetrating matter. The spatial broadening of the ion beam presents an ultimate limit to the resolving power that can be achieved in nuclear microscopy methods. The pressing of the attainable resolution limit in biomedical nuclear microscopy to dimensions approaching 10 nm, or so, implies the fundamental limitation from ion-target scattering will become increasingly significant. This effect has been investigated by a combined analytical and numerical computational approach to determine the extent and how single and multiple scattering processes limit the resolution for analysis with 2 MeV 4He and 1H ions of realistic biomedical samples. The cases studied were direct-Scanning Transmission Ion Microscopy (direct-STIM), Particle Induced X-ray Emission (PIXE) studies of 20 μm tissue sections and in vivo single-ion irradiation of cells. © 2009 Elsevier B.V. All rights reserved.
Source Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
URI: http://scholarbank.nus.edu.sg/handle/10635/95787
ISSN: 0168583X
DOI: 10.1016/j.nimb.2009.03.063
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