Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0an00943a
Title: An effective real-time colorimeteric sensor for sensitive and selective detection of cysteine under physiological conditions
Authors: Yan, Z.
Guang, S.
Xu, H.
Liu, X. 
Issue Date: 7-May-2011
Citation: Yan, Z., Guang, S., Xu, H., Liu, X. (2011-05-07). An effective real-time colorimeteric sensor for sensitive and selective detection of cysteine under physiological conditions. Analyst 136 (9) : 1916-1921. ScholarBank@NUS Repository. https://doi.org/10.1039/c0an00943a
Abstract: In this contribution, a new, real-time and sensitive colorimetric sensor, di-N-methyl-N-hydroxyethylaniline squaraine (SQ), has been identified and synthesized for cysteine analysis based on its ΔA in neutral aqueous medium (pH ≈ 7.5). The proposed method was applied to analyse synthetic amino acid samples and human serum samples. The results show that the linear range of cysteine detection in aqueous medium at pH ≈ 7.5 is 10∼700 nmol L -1 with a correlation coefficient (R) of 0.9984 and a limit of detection (3σ, n = 20) of 3.9 nmol L-1. The relative standard deviation (RSD) for cysteine detection was lower than 4.1% (n = 5). The proposed method possesses the advantages of simplicity, rapidity, high selectivity and sensitivity. This makes it possible, for the first time, the real-time detection of cysteine under normal physiological conditions. © 2011 The Royal Society of Chemistry.
Source Title: Analyst
URI: http://scholarbank.nus.edu.sg/handle/10635/95760
ISSN: 00032654
DOI: 10.1039/c0an00943a
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