Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(97)00940-3
Title: Absence of aluminium in neurofibrillary tangles in Alzheimer's disease
Authors: Makjanic, J. 
McDonald, B.
Li-Hsian Chen, C.P.
Watt, F. 
Keywords: Aluminium
Alzheimer's disease
Neurofibrillary tangles
Nuclear microscopy
Issue Date: 16-Jan-1998
Citation: Makjanic, J., McDonald, B., Li-Hsian Chen, C.P., Watt, F. (1998-01-16). Absence of aluminium in neurofibrillary tangles in Alzheimer's disease. Neuroscience Letters 240 (3) : 123-126. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(97)00940-3
Abstract: Using the new technique of nuclear microscopy, aluminium is not detected in pyramidal neurons in brain tissue from Alzheimer's disease (AD) patients. The analytical technique of nuclear microscopy can simultaneously image and analyse features in unstained and untreated tissue sections. In tissue which had been previously subjected to conventional procedures such as fixation and osmication, aluminium was observed in both neurons and surrounding tissue. This result shows that the analysis of tissue prepared using conventional chemical techniques may produce contamination or elemental redistribution, and supports our previous investigations which implied that aluminium is not involved in the aetiology of AD. In addition, significant increases in iron, phosphorus and sulphur concentrations were noted between neurons from Alzheimer tissue and neurons from age-matched controls, and between the supporting Alzheimer tissue and supporting control tissue, implying an overall increase in these elements. No significant increase in calcium was observed between neurons from Alzheimer tissue and neurons from age-matched controls.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/95714
ISSN: 03043940
DOI: 10.1016/S0304-3940(97)00940-3
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on Dec 12, 2018

WEB OF SCIENCETM
Citations

27
checked on Dec 12, 2018

Page view(s)

19
checked on Sep 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.