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Title: Defensins: Antimicrobial peptides for therapeutic development
Authors: Verma, C. 
Seebah, S.
Low, S.M.
Zhou, L.
Liu, S.P. 
Li, J.
Beuerman, R.W.
Keywords: Anti-infectives
Innate immunity
Novel analogues
Issue Date: Nov-2007
Source: Verma, C.,Seebah, S.,Low, S.M.,Zhou, L.,Liu, S.P.,Li, J.,Beuerman, R.W. (2007-11). Defensins: Antimicrobial peptides for therapeutic development. Biotechnology Journal 2 (11) : 1353-1359. ScholarBank@NUS Repository.
Abstract: A novel class of endogenous antimicrobial peptides called defensins has shown great versatility in their activity against a diverse range of microorganisms including bacteria, viruses and fungi. Their mode of action of bacterial cell lysis seems largely nonspecific and so promises to avert the development of resistance. These two features have made them an area of intense research activity and growing commercial interest. A successful multidisciplinary effort to investigate and develop novel defensins analogues has been established in Singapore that involves computer modeling, biochemistry, proteomics, chemical synthesis, molecular biology and clinical sciences. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Biotechnology Journal
ISSN: 18606768
DOI: 10.1002/biot.200700148
Appears in Collections:Staff Publications

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