Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/95536
Title: Pleiotropic effects of red yeast rice (Monascus Purpureus)
Authors: Wei, Y.
Popovich, D.G. 
Keywords: Ankaflavin
Monascorubramine
Monascus purpureus
Red yeast rice
Rubropunctamine
Issue Date: Mar-2012
Citation: Wei, Y.,Popovich, D.G. (2012-03). Pleiotropic effects of red yeast rice (Monascus Purpureus). Bioactive Compounds: Types, Biological Activities and Health Effects : 307-318. ScholarBank@NUS Repository.
Abstract: Red yeast rice (Monascus purpureus fermented rice) has traditionally been used as a natural food colorant and food preservative of meat and fish for centuries in Asia. It has become a popular dietary supplement due to monacolins, some of which can lower serum cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA). Monacolin K, the major monacolin found in red yeast rice is structurally identical to lovastatin; however monacolin K possess other pleiotropic effects which include and ability to induce cell apoptosis and decrease cellular triglyceride, cholesterol, and free fatty acid production by down-regulation of fatty acid synthase that is linked to decreased Akt activation and relation of peroxisome proliferator-activated receptor (PPAR)-γ. Beyond the effect of monacolin K on cholesterol metabolism, red yeast rice has anti-oxidant and anti-inflammatory properties that may convey additional bioactive effects. Red yeast rice extracts were shown to inhibit proliferation and induce apoptosis in various cancer cells. Pigments extracted from red yeast rice have also been shown to possess potential chemo-preventative properties. The red pigments rubropunctamine and monascorubramine displayed strong cytotoxicity. The dehydrogenated derivatives of the red rice pigments rubropunctamine and monascorubramine also have been reported to have cytotoxic properties. Ankaflavin, a yellow pigment from red yeast rice exhibited antitumor-initiating effects on cancer progression. This review will focus on reviewing the potential structure function effects of red yeast rice extracts in cancer cell models as well as detailing the chemical structures of the potential bioactive components. © 2012 Nova Science Publishers, Inc. All rights reserved.
Source Title: Bioactive Compounds: Types, Biological Activities and Health Effects
URI: http://scholarbank.nus.edu.sg/handle/10635/95536
ISBN: 9781613248652
Appears in Collections:Staff Publications

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