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|Title:||The use of click chemistry in the emerging field of catalomics|
|Source:||Kalesh, K.A., Shi, H., Ge, J., Yao, S.Q. (2010). The use of click chemistry in the emerging field of catalomics. Organic and Biomolecular Chemistry 8 (8) : 1749-1762. ScholarBank@NUS Repository. https://doi.org/10.1039/b923331h|
|Abstract:||Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments. © 2010 The Royal Society of Chemistry.|
|Source Title:||Organic and Biomolecular Chemistry|
|Appears in Collections:||Staff Publications|
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