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https://doi.org/10.1002/anie.201006316
Title: | The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives | Authors: | Luo, J. Wang, H. Han, X. Xu, L.-W. Kwiatkowski, J. Huang, K.-W. Lu, Y. |
Keywords: | aldol reaction asymmetric synthesis butenolides glycerol derivatives organocatalysis |
Issue Date: | 18-Feb-2011 | Citation: | Luo, J., Wang, H., Han, X., Xu, L.-W., Kwiatkowski, J., Huang, K.-W., Lu, Y. (2011-02-18). The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives. Angewandte Chemie - International Edition 50 (8) : 1861-1864. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201006316 | Abstract: | Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. The reported method led to the synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile synthesis of chiral glycerol derivatives containing a tertiary hydroxy group has also been demonstrated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/95219 | ISSN: | 14337851 | DOI: | 10.1002/anie.201006316 |
Appears in Collections: | Staff Publications |
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