Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201006316
Title: The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives
Authors: Luo, J.
Wang, H.
Han, X.
Xu, L.-W.
Kwiatkowski, J.
Huang, K.-W.
Lu, Y. 
Keywords: aldol reaction
asymmetric synthesis
butenolides
glycerol derivatives
organocatalysis
Issue Date: 18-Feb-2011
Citation: Luo, J., Wang, H., Han, X., Xu, L.-W., Kwiatkowski, J., Huang, K.-W., Lu, Y. (2011-02-18). The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives. Angewandte Chemie - International Edition 50 (8) : 1861-1864. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201006316
Abstract: Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. The reported method led to the synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile synthesis of chiral glycerol derivatives containing a tertiary hydroxy group has also been demonstrated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/95219
ISSN: 14337851
DOI: 10.1002/anie.201006316
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