Please use this identifier to cite or link to this item:
|Title:||Synthesis of sulfur-substituted α-stereogenic amides and ketones: Highly enantioselective sulfa-michael additions of 1,4-dicarbonylbut-2-enes|
|Keywords:||α-stereogenic amides and ketones|
|Citation:||Zhao, F., Zhang, W., Yang, Y., Pan, Y., Chen, W., Liu, H., Yan, L., Tan, C.-H., Jiang, Z. (2011-10). Synthesis of sulfur-substituted α-stereogenic amides and ketones: Highly enantioselective sulfa-michael additions of 1,4-dicarbonylbut-2-enes. Advanced Synthesis and Catalysis 353 (14-15) : 2624-2630. ScholarBank@NUS Repository.|
|Abstract:||Conjugate addition to 1,4-dicarbonylbut-2-enes will generate an α-stereogenic center with respect to one of the carbonyl groups, which informally, can be considered as an inversion of normal reactivity patterns or umpolung protocol. In this paper, the addition of tert-butyl mercaptan to 1,4-dicarbonylbut-2-enes including (E)-4-oxo-4-arylbutenamides and (E)-4-oxo-4-arylbutenones has been developed, to synthesize a series of chiral sulfur-substituted α-stereogenic amides and ketones in high regioselectivity and enantioselectivity (up to 98% ee). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Advanced Synthesis and Catalysis|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 10, 2018
WEB OF SCIENCETM
checked on May 15, 2018
checked on Jul 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.