Please use this identifier to cite or link to this item:
|Title:||Synthesis and disulfide bond connectivity-activity studies of a kalata B1-inspired cyclopeptide against dengue NS2B-NS3 protease|
|Keywords:||Dengue NS2B-NS3 protease|
|Source:||Gao, Y., Cui, T., Lam, Y. (2010-02-01). Synthesis and disulfide bond connectivity-activity studies of a kalata B1-inspired cyclopeptide against dengue NS2B-NS3 protease. Bioorganic and Medicinal Chemistry 18 (3) : 1331-1336. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmc.2009.12.026|
|Abstract:||Kalata B1 is a plant protein with remarkable thermal, chemical and enzymatic stability. Its potential applications could be centered on the possibility of using its cyclic structure and cystine knot motif as a scaffold for the design of stable pharmaceuticals. To discover potent dengue NS2B-NS3 protease inhibitors, we have prepared various kalata B1 analogues by varying the amino acid sequence. Mass spectrometric and biochemical investigations of these analogues revealed a cyclopeptide whose two fully oxidized forms are substrate-competitive inhibitors of the dengue viral NS2B-NS3 protease. Both oxidized forms showed potent inhibition with Ki of 1.39 ± 0.35 and 3.03 ± 0.75 μM, respectively. © 2009 Elsevier Ltd. All rights reserved.|
|Source Title:||Bioorganic and Medicinal Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 12, 2018
WEB OF SCIENCETM
checked on Nov 19, 2017
checked on Feb 16, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.