Please use this identifier to cite or link to this item: https://doi.org/10.1021/om300444c
Title: Syntheses, characterizations, and a preliminary comparative cytotoxicity study of gold(I) and gold(III) complexes bearing benzimidazole- and pyrazole-derived N-heterocyclic carbenes
Authors: Sivaram, H.
Tan, J.
Huynh, H.V. 
Issue Date: 27-Aug-2012
Citation: Sivaram, H., Tan, J., Huynh, H.V. (2012-08-27). Syntheses, characterizations, and a preliminary comparative cytotoxicity study of gold(I) and gold(III) complexes bearing benzimidazole- and pyrazole-derived N-heterocyclic carbenes. Organometallics 31 (16) : 5875-5883. ScholarBank@NUS Repository. https://doi.org/10.1021/om300444c
Abstract: A series of Au(I) and Au(III) mono-, homobis-, and heterobis(carbene) complexes, [AuCl(FPyr)] (2), [Au( iPr 2-bimy) 2]PF 6 (3), [Au(FPyr) 2]PF 6 (4), [Au(FPyr)( iPr 2-bimy)]PF 6 (5), [AuCl 3( iPr 2-bimy)] (6), [AuCl 3(FPyr)] (7), [AuCl 2( iPr 2-bimy) 2]PF 6 (8), [AuCl 2(FPyr) 2]PF 6 (9), and [AuCl 2(FPyr)( iPr 2-bimy)]PF 6 (10), bearing the benzimidazole-derived iPr 2-bimy (1,3-diisopropylbenzimidazolin-2-ylidene) and/or the pyrazole-derived FPyr (1,2,3,4,6,7,8,9-octahydropyridazino[1,2-a]indazolin-11-ylidene) N-heterocyclic carbene (NHC) ligands have been synthesized. Complexes 2-10 have been fully characterized using multinuclei NMR spectroscopy, ESI mass spectrometry, and elemental analysis. X-ray diffraction analyses have been performed on 2, 3, 5, 6, and 8. Together with the previously reported [AuCl( iPr 2-bimy)] (1), the cytotoxic activities of all 10 complexes have been studied in vitro with the NCI-H1666 non-small cell lung cancer cell line. The cationic bis(carbene) complexes 3-5 and 8-10 show better cytotoxicity in comparison to cisplatin. In particular, the heterobis(carbene) complexes 5 and 10 have superior activity, with IC 50 values of around 0.2 μM. © 2012 American Chemical Society.
Source Title: Organometallics
URI: http://scholarbank.nus.edu.sg/handle/10635/95017
ISSN: 02767333
DOI: 10.1021/om300444c
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

55
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

52
checked on Jun 27, 2018

Page view(s)

29
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.