Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol0275567
Title: Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases
Authors: Wang, G.
Mahesh, U. 
Chen, G.Y.J. 
Yao, S.Q. 
Issue Date: 6-Mar-2003
Citation: Wang, G., Mahesh, U., Chen, G.Y.J., Yao, S.Q. (2003-03-06). Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases. Organic Letters 5 (5) : 737-740. ScholarBank@NUS Repository. https://doi.org/10.1021/ol0275567
Abstract: (Matrix presented) Peptide vinyl sulfones were prepared from 2-chlorotrityl resin-bound phenolic amino vinyl sulfones in high yield and purity. This method enables the convenient synthesis of peptide vinyl sulfones having different amino acids at the P1 position. It also allows efficient synthesis of vinyl sulfone-containing, activity-based probes of cysteine proteases used in a proteomic experiment.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/94834
ISSN: 15237060
DOI: 10.1021/ol0275567
Appears in Collections:Staff Publications

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