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|Title:||Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives|
|Citation:||Lee, C.L., Lam, Y., Lee, S.-Y. (2001-01-01). Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives. Tetrahedron Letters 42 (1) : 109-111. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(00)01896-7|
|Abstract:||Bis-(2-nitro-4-carboxyphenyl) disulfide was loaded on Wang resin and Rink amide resin. The nitro group was reduced to its amine with concomitant cleavage of the disulfide bond using SnCl2-2H2O to afford 2. Condensation of an aldehyde and nucleophilic attack on an α,β-unsaturated ketone, followed by TFA cleavage from the resin, gave benzothiazole 3 and 2,3-dihydro-[1,5]-benzothiazepine 4, respectively. © 2000 Elsevier Science Ltd.|
|Source Title:||Tetrahedron Letters|
|Appears in Collections:||Staff Publications|
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