Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(00)01896-7
Title: Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives
Authors: Lee, C.L.
Lam, Y. 
Lee, S.-Y. 
Keywords: 2,3-dihydro-[1,5]-benzothiazepine
Benzothiazole
Solid-phase synthesis
Issue Date: 1-Jan-2001
Citation: Lee, C.L., Lam, Y., Lee, S.-Y. (2001-01-01). Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives. Tetrahedron Letters 42 (1) : 109-111. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(00)01896-7
Abstract: Bis-(2-nitro-4-carboxyphenyl) disulfide was loaded on Wang resin and Rink amide resin. The nitro group was reduced to its amine with concomitant cleavage of the disulfide bond using SnCl2-2H2O to afford 2. Condensation of an aldehyde and nucleophilic attack on an α,β-unsaturated ketone, followed by TFA cleavage from the resin, gave benzothiazole 3 and 2,3-dihydro-[1,5]-benzothiazepine 4, respectively. © 2000 Elsevier Science Ltd.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/94832
ISSN: 00404039
DOI: 10.1016/S0040-4039(00)01896-7
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