Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2006.08.018
Title: Single laboratory validation of a method for the determination of Bisphenol A, Bisphenol A diglycidyl ether and its derivatives in canned foods by reversed-phase liquid chromatography
Authors: Sun, C.
Leong, L.P. 
Barlow, P.J. 
Chan, S.H.
Bloodworth, B.C.
Keywords: Bisphenol A (BPA)
Bisphenol A diglycidyl ether (BADGE)
Can coatings
High-performance liquid chromatography (HPLC)
Migration
Issue Date: 29-Sep-2006
Citation: Sun, C., Leong, L.P., Barlow, P.J., Chan, S.H., Bloodworth, B.C. (2006-09-29). Single laboratory validation of a method for the determination of Bisphenol A, Bisphenol A diglycidyl ether and its derivatives in canned foods by reversed-phase liquid chromatography. Journal of Chromatography A 1129 (1) : 145-148. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2006.08.018
Abstract: A method was developed and validated for the simultaneous determination of Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE), BADGE-H2O, BADGE-2H2O, BADGE-H2O-HCl, BADGE-HCl, and BADGE-2HCl in canned food using reversed phase high-performance liquid chromatography (HPLC) with fluorescence detection; chromatographic separation of all seven analytes was achieved (Rs ≥ 1.08) using HPLC gradient elution technique. Acetonitrile was used to extract the analytes from the food matrix before subjecting the samples to liquid-liquid extraction, solid-phase extraction for further clean-up and preconcentration prior to HPLC analysis. Excellent inter-day precision data (n = 10) and intra-day precision data (n = 5) were obtained on a 200 μg/kg spiked sample. The RSD ranged from 0.20% to 2.96% for the inter-day precision tests, and 0.04% to 2.82% for the intra-day precision tests. Accuracy was measured at three concentration levels: 200, 1000, and 2000 μg/kg; recoveries ranged from 86.07% to 114.06%. The excellent validation data suggests that this method can be applied on canned foods for the determination of migration of BPA, BADGE and its derivatives from can coatings into food. © 2006 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/94815
ISSN: 00219673
DOI: 10.1016/j.chroma.2006.08.018
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