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Title: Phenylcarbamoylated β-CD: π-acidic and π-basic chiral selectors for HPLC
Authors: Lin, C.
Luo, W.
Zhang, S. 
Zhang, Z.
Zhang, W.
Zheng, S.
Fan, J.
Li, W.
Qin, Q.
Guo, Z.
Keywords: π-acidic and π-basic β-CD chiral stationary phases
Chiral separation
Issue Date: Jun-2010
Citation: Lin, C., Luo, W., Zhang, S., Zhang, Z., Zhang, W., Zheng, S., Fan, J., Li, W., Qin, Q., Guo, Z. (2010-06). Phenylcarbamoylated β-CD: π-acidic and π-basic chiral selectors for HPLC. Journal of Separation Science 33 (11) : 1558-1562. ScholarBank@NUS Repository.
Abstract: Two types of chiral stationary phases for HPLC based on π-acidic or π-basic perphenylcarbamoylated β-CDs were synthesized. The relative structural features of the two effective chiral selectors are discussed and compared in both normal-phase and RP modes. In addition, the nature and concentration of alcoholic modifiers were varied for optimal separation in normal phase and the structural variation of the analytes was also examined. The results showed that hydrogen bonding, steric effect and π-acidic-π-basic interaction contributed greatly to enantioseparation. Upon comparison, some of the differences in the separation behavior of the two types of chiral stationary phases might be due to the π-acidic or π-basic phenylcarbamate groups. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: Journal of Separation Science
ISSN: 16159306
DOI: 10.1002/jssc.200900826
Appears in Collections:Staff Publications

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