Please use this identifier to cite or link to this item: https://doi.org/10.1002/cmdc.200800069
Title: Osmium carbonyl clusters: A new class of apoptosis inducing agents
Authors: Kong, K.V.
Leong, W.K. 
Ng, S.P.
Nguyen, T.H.
Lim, L.H.K.
Keywords: Antitumor agents
Apoptosis
Cancer
Cluster compounds
Osmium
Issue Date: 18-Aug-2008
Citation: Kong, K.V., Leong, W.K., Ng, S.P., Nguyen, T.H., Lim, L.H.K. (2008-08-18). Osmium carbonyl clusters: A new class of apoptosis inducing agents. ChemMedChem 3 (8) : 1269-1275. ScholarBank@NUS Repository. https://doi.org/10.1002/cmdc.200800069
Abstract: Osmium carbonyl clusters, especially the cluster [Os3(CO) 10-(NCCH3)2], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number ofmorpho logical and apoptosis assays, all ofwhich pointed to the induction of apoptosis. © 2008 Wiley-VCH Verlag GmbH& Co. KGaA.
Source Title: ChemMedChem
URI: http://scholarbank.nus.edu.sg/handle/10635/94463
ISSN: 18607179
DOI: 10.1002/cmdc.200800069
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