Please use this identifier to cite or link to this item:
|Title:||Organoruthenium antagonists of human A3 adenosine receptors|
|Authors:||Paira, P. |
|Citation:||Paira, P., Chow, M.J., Venkatesan, G., Kosaraju, V.K., Cheong, S.L., Klotz, K.-N., Ang, W.H., Pastorin, G. (2013-06-17). Organoruthenium antagonists of human A3 adenosine receptors. Chemistry - A European Journal 19 (25) : 8321-8330. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201203291|
|Abstract:||Human A3 adenosine receptor (hA3AR) is a membrane-bound G protein-coupled receptor implicated in a number of severe pathological conditions, including cancer, in which it acts as a potential therapeutic target. To derive structure-activity relationships on pyrazolo-triazolo-pyrimidine (PTP)-based A3AR antagonists, we developed a new class of organometallic inhibitors through replacement of the triazolo moiety with an organoruthenium fragment. The objective was to introduce by design structural diversity into the PTP scaffold in order to tune their binding efficacy toward the target receptor. These novel organoruthenium antagonists displayed good aquatic stability and moderate binding affinity toward the hA3 receptor in the low micromolar range. The assembly of these complexes through a template-driven approach with selective ligand replacement at the metal center to control their steric and receptor-binding properties is discussed. Scaffold design: A novel class of ruthenium(II)-arene complexes containing chelating N,N-pyrazolo-pyrimidine ligands was rationally developed to be selective antagonists of human A3 adenosine receptors based on the proven pyrazolo-triazolo-pyrimidine design (see figure). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Chemistry - A European Journal|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 23, 2019
WEB OF SCIENCETM
checked on Mar 13, 2019
checked on Mar 16, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.