Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/94436
Title: Optimization of liquid chromatographic parameters for the separation of priority phenols by using mixed-level orthogonal array design
Authors: Chee, K.K.
Lan, W.G.
Wong, M.K. 
Lee, H.K. 
Keywords: Chemometrics
Liquid chromatography
Mixed-level orthogonal array design
Phenols
Substituted phenols
Issue Date: 11-Sep-1995
Source: Chee, K.K.,Lan, W.G.,Wong, M.K.,Lee, H.K. (1995-09-11). Optimization of liquid chromatographic parameters for the separation of priority phenols by using mixed-level orthogonal array design. Analytica Chimica Acta 312 (3) : 271-280. ScholarBank@NUS Repository.
Abstract: Mixed-level orthogonal array design (OAD) as a chemometric method has been employed to optimize liquid Chromatographic (LC) conditions for the separation of environmental pollutants. Six parameters were examined by OAD, namely reversed-phase (C18) LC columns from different manufacturers, content of methanol and acetonitrile in the mobile phase, initial time-duration of a fixed mobile phase composition, time-duration of a gradient elution programme, and mobile phase flow rate. The optimization of these parameters for the determination of eleven priority substituted phenols was carried out to demonstrate the applicability of mixed-level OAD in environmental analytical chemistry in which the use of trial-and-error procedures is often unsatisfactory due to sample complexity. The advantages and the disadvantages of mixed-level OAD were discussed. © 1995.
Source Title: Analytica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/94436
ISSN: 00032670
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

22
checked on Feb 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.