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|Title:||Optimization of liquid chromatographic parameters for the separation of priority phenols by using mixed-level orthogonal array design|
Mixed-level orthogonal array design
|Source:||Chee, K.K.,Lan, W.G.,Wong, M.K.,Lee, H.K. (1995-09-11). Optimization of liquid chromatographic parameters for the separation of priority phenols by using mixed-level orthogonal array design. Analytica Chimica Acta 312 (3) : 271-280. ScholarBank@NUS Repository.|
|Abstract:||Mixed-level orthogonal array design (OAD) as a chemometric method has been employed to optimize liquid Chromatographic (LC) conditions for the separation of environmental pollutants. Six parameters were examined by OAD, namely reversed-phase (C18) LC columns from different manufacturers, content of methanol and acetonitrile in the mobile phase, initial time-duration of a fixed mobile phase composition, time-duration of a gradient elution programme, and mobile phase flow rate. The optimization of these parameters for the determination of eleven priority substituted phenols was carried out to demonstrate the applicability of mixed-level OAD in environmental analytical chemistry in which the use of trial-and-error procedures is often unsatisfactory due to sample complexity. The advantages and the disadvantages of mixed-level OAD were discussed. © 1995.|
|Source Title:||Analytica Chimica Acta|
|Appears in Collections:||Staff Publications|
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